Cellular and hormonal content of breast nipple aspirate fluid in relation to the risk of breast cancer

Seema A. Khan*, Robert T. Chatterton

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

In research settings, the measurement of serum and urine hormone concentrations has shown modest positive relationships with breast cancer risk in postmenopausal women. However, the local production of sex steroids in the breast is a significant contributor to the hormonal environment of the breast. Nipple aspiration fluid provides a window into this environment and allows the measurement of hormone and protein content which may show stronger relations to breast cancef risk, and therefore enable both more accurate risk assessment, and the use of preventive measures directed to the lowering of local breast hormonal exposure.

Original languageEnglish (US)
Pages (from-to)479-493
Number of pages15
JournalBiomarkers in Medicine
Volume2
Issue number5
DOIs
StatePublished - 2008

Keywords

  • Breast cancer
  • Cytologic atypia
  • Estradiol
  • Estrogen-response proteins
  • Hormones
  • Nipple aspiration fluid
  • Risk

ASJC Scopus subject areas

  • Drug Discovery
  • Clinical Biochemistry
  • Biochemistry, medical

Fingerprint Dive into the research topics of 'Cellular and hormonal content of breast nipple aspirate fluid in relation to the risk of breast cancer'. Together they form a unique fingerprint.

Cite this