Cellular and molecular guidance of GABAergic neuronal migration from an extracortical origin to the neocortex

Yan Zhu, Hua Shun Li, Lijuan Zhou, Jane Y. Wu, Yi Rao*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

211 Scopus citations

Abstract

Formation of the normal mammalian cerebral cortex requires the migration of GABAergic inhibitory interneurons from an extracortical origin, the lateral ganglionic eminence (LGE). Mechanisms guiding the migratory direction of these neurons, or other neurons in the neocortex, are not well understood. We have used an explant assay to study GABAergic neuronal migration and found that the ventricular zone (VZ) of the LGE is repulsive to GABAergic neurons. Furthermore, the secreted protein Slit is a chemorepellent guiding the migratory direction of GABAergic neurons, and blockade of endogenous Slit signaling inhibits the repulsive activity in the VZ. These results have revealed a cellular source of guidance for GABAergic neurons, demonstrated a molecular cue important for cortical development, and suggested a guidance mechanism for the migration of extracortical neurons into the neocortex.

Original languageEnglish (US)
Pages (from-to)473-485
Number of pages13
JournalNeuron
Volume23
Issue number3
DOIs
StatePublished - Jul 1999

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint

Dive into the research topics of 'Cellular and molecular guidance of GABAergic neuronal migration from an extracortical origin to the neocortex'. Together they form a unique fingerprint.

Cite this