Cellular and Molecular Mechanisms of Vascular Lumen Formation

M. Luisa Iruela-Arispe*, George E. Davis

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

232 Scopus citations


The formation of vascular lumens by endothelial cells is a critical step in the angiogenic process that occurs during invasion and growth of the incipient vascular sprout. Once a lumen is established, capillaries are rapidly exposed to the physical forces associated with the flow of blood which, together with genetic information, regulate the ultimate size of inner vessel diameter. Here we review the recent literature on vascular lumen formation and compare it to lumen formation in other epithelial systems. We also discuss the regulation of lumen diameter after vascular morphogenesis has been completed.

Original languageEnglish (US)
Pages (from-to)222-231
Number of pages10
JournalDevelopmental Cell
Issue number2
StatePublished - Feb 17 2009

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology


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