Cellular mechanics in human blood eosinophils and leukotriene C 4 synthesis

Christopher M. Waters*, Ushma Savla, Pam Kuagoolwongse, Peter H Sporn

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review

Abstract

Cellular mechanics in human blood eosinophils and leukotriene C 4 (LTC4) synthesis were studied. The inhibition of LTC4 synthesis was sustained for 2 hours after initial stretch treatment. It was demonstrated that the cyclic mechanical strain inhibits LTC4 synthesis by adherent eosinophils in a frequency-dependent and relaxation time-dependent manner.

Original languageEnglish (US)
Pages (from-to)635-636
Number of pages2
JournalAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
Volume50
StatePublished - Dec 1 2001
EventProceedings of the 2001 Bioengineering Conference - Snowbird, UT, United States
Duration: Jun 27 2001Jul 1 2001

ASJC Scopus subject areas

  • Engineering(all)

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