Cellular mechanics in human blood eosinophils and leukotriene C 4 (LTC4) synthesis were studied. The inhibition of LTC4 synthesis was sustained for 2 hours after initial stretch treatment. It was demonstrated that the cyclic mechanical strain inhibits LTC4 synthesis by adherent eosinophils in a frequency-dependent and relaxation time-dependent manner.
|Original language||English (US)|
|Number of pages||2|
|Journal||American Society of Mechanical Engineers, Bioengineering Division (Publication) BED|
|State||Published - Dec 1 2001|
|Event||Proceedings of the 2001 Bioengineering Conference - Snowbird, UT, United States|
Duration: Jun 27 2001 → Jul 1 2001
ASJC Scopus subject areas