Cellular origins and genetic landscape of cutaneous gamma delta T cell lymphomas

Jay Daniels, Peter G. Doukas, Maria E.Martinez Escala, Kimberly G. Ringbloom, David J.H. Shih, Jingyi Yang, Kyle Tegtmeyer, Joonhee Park, Jane J. Thomas, Mehmet E. Selli, Can Altunbulakli, Ragul Gowthaman, Samuel H. Mo, Balaji Jothishankar, David R. Pease, Barbara Pro, Farah R. Abdulla, Christopher Shea, Nidhi Sahni, Alejandro A. GruBrian G. Pierce, Abner Louissaint, Joan Guitart*, Jaehyuk Choi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Primary cutaneous γδ T cell lymphomas (PCGDTLs) represent a heterogeneous group of uncommon but aggressive cancers. Herein, we perform genome-wide DNA, RNA, and T cell receptor (TCR) sequencing on 29 cutaneous γδ lymphomas. We find that PCGDTLs are not uniformly derived from Vδ2 cells. Instead, the cell-of-origin depends on the tissue compartment from which the lymphomas are derived. Lymphomas arising from the outer layer of skin are derived from Vδ1 cells, the predominant γδ cell in the epidermis and dermis. In contrast, panniculitic lymphomas arise from Vδ2 cells, the predominant γδ T cell in the fat. We also show that TCR chain usage is non-random, suggesting common antigens for Vδ1 and Vδ2 lymphomas respectively. In addition, Vδ1 and Vδ2 PCGDTLs harbor similar genomic landscapes with potentially targetable oncogenic mutations in the JAK/STAT, MAPK, MYC, and chromatin modification pathways. Collectively, these findings suggest a paradigm for classifying, staging, and treating these diseases.

Original languageEnglish (US)
Article number1806
JournalNature communications
Issue number1
StatePublished - Dec 1 2020

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)


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