Cellular principles underlying normal and pathological activity in the subthalamic nucleus

Mark D. Bevan; Jeremy F. Atherton; Jérôme Baufreton

doi:10.1016/j.conb.2006.10.003

Cellular principles underlying normal and pathological activity in the subthalamic nucleus

Mark D. Bevan^*, Jeremy F. Atherton, Jérôme Baufreton

^*Corresponding author for this work

Neuroscience

Research output: Contribution to journal › Review article › peer-review

81 Scopus citations

Abstract

The motor symptoms of Parkinson's disease are associated with abnormal, correlated, low frequency, rhythmic burst activity in the subthalamic nucleus and connected nuclei. Research into the mechanisms controlling the pattern of subthalamic activity has intensified because therapies that manipulate the pattern of subthalamic activity, such as deep brain stimulation and levodopa administration, improve motor function in Parkinson's disease. Recent findings suggest that dopamine denervation of the striatum and extrastriatal basal ganglia profoundly alters the transmission and integration of glutamatergic cortical and GABAergic pallidal inputs to subthalamic neurons, leading to pathological activity that resonates throughout the basal ganglia and wider motor system.

Original language	English (US)
Pages (from-to)	621-628
Number of pages	8
Journal	Current opinion in neurobiology
Volume	16
Issue number	6
DOIs	https://doi.org/10.1016/j.conb.2006.10.003
State	Published - Dec 2006

Funding

Our work is supported by National Institutes of Health –National Institute of Neurological Disorders and Stroke Grants NS041280, NS20702, NS040705 and a Parkinson Disease Foundation Mega Grant to MD Bevan, and a L’Association France Parkinson Fellowship to J Baufreton.

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.conb.2006.10.003

Cite this

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title = "Cellular principles underlying normal and pathological activity in the subthalamic nucleus",

abstract = "The motor symptoms of Parkinson's disease are associated with abnormal, correlated, low frequency, rhythmic burst activity in the subthalamic nucleus and connected nuclei. Research into the mechanisms controlling the pattern of subthalamic activity has intensified because therapies that manipulate the pattern of subthalamic activity, such as deep brain stimulation and levodopa administration, improve motor function in Parkinson's disease. Recent findings suggest that dopamine denervation of the striatum and extrastriatal basal ganglia profoundly alters the transmission and integration of glutamatergic cortical and GABAergic pallidal inputs to subthalamic neurons, leading to pathological activity that resonates throughout the basal ganglia and wider motor system.",

author = "Bevan, {Mark D.} and Atherton, {Jeremy F.} and J{\'e}r{\^o}me Baufreton",

note = "Funding Information: Our work is supported by National Institutes of Health –National Institute of Neurological Disorders and Stroke Grants NS041280, NS20702, NS040705 and a Parkinson Disease Foundation Mega Grant to MD Bevan, and a L{\textquoteright}Association France Parkinson Fellowship to J Baufreton.",

year = "2006",

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doi = "10.1016/j.conb.2006.10.003",

language = "English (US)",

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journal = "Current opinion in neurobiology",

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AU - Bevan, Mark D.

AU - Atherton, Jeremy F.

AU - Baufreton, Jérôme

N1 - Funding Information: Our work is supported by National Institutes of Health –National Institute of Neurological Disorders and Stroke Grants NS041280, NS20702, NS040705 and a Parkinson Disease Foundation Mega Grant to MD Bevan, and a L’Association France Parkinson Fellowship to J Baufreton.

PY - 2006/12

Y1 - 2006/12

N2 - The motor symptoms of Parkinson's disease are associated with abnormal, correlated, low frequency, rhythmic burst activity in the subthalamic nucleus and connected nuclei. Research into the mechanisms controlling the pattern of subthalamic activity has intensified because therapies that manipulate the pattern of subthalamic activity, such as deep brain stimulation and levodopa administration, improve motor function in Parkinson's disease. Recent findings suggest that dopamine denervation of the striatum and extrastriatal basal ganglia profoundly alters the transmission and integration of glutamatergic cortical and GABAergic pallidal inputs to subthalamic neurons, leading to pathological activity that resonates throughout the basal ganglia and wider motor system.

AB - The motor symptoms of Parkinson's disease are associated with abnormal, correlated, low frequency, rhythmic burst activity in the subthalamic nucleus and connected nuclei. Research into the mechanisms controlling the pattern of subthalamic activity has intensified because therapies that manipulate the pattern of subthalamic activity, such as deep brain stimulation and levodopa administration, improve motor function in Parkinson's disease. Recent findings suggest that dopamine denervation of the striatum and extrastriatal basal ganglia profoundly alters the transmission and integration of glutamatergic cortical and GABAergic pallidal inputs to subthalamic neurons, leading to pathological activity that resonates throughout the basal ganglia and wider motor system.

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JO - Current opinion in neurobiology

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Cellular principles underlying normal and pathological activity in the subthalamic nucleus

Abstract

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