Cellular principles underlying normal and pathological activity in the subthalamic nucleus

Mark D. Bevan*, Jeremy F. Atherton, Jérôme Baufreton

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

67 Scopus citations

Abstract

The motor symptoms of Parkinson's disease are associated with abnormal, correlated, low frequency, rhythmic burst activity in the subthalamic nucleus and connected nuclei. Research into the mechanisms controlling the pattern of subthalamic activity has intensified because therapies that manipulate the pattern of subthalamic activity, such as deep brain stimulation and levodopa administration, improve motor function in Parkinson's disease. Recent findings suggest that dopamine denervation of the striatum and extrastriatal basal ganglia profoundly alters the transmission and integration of glutamatergic cortical and GABAergic pallidal inputs to subthalamic neurons, leading to pathological activity that resonates throughout the basal ganglia and wider motor system.

Original languageEnglish (US)
Pages (from-to)621-628
Number of pages8
JournalCurrent opinion in neurobiology
Volume16
Issue number6
DOIs
StatePublished - Dec 1 2006

ASJC Scopus subject areas

  • Neuroscience(all)

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