Cellular responses of bioabsorbable polymeric material and Guglielmi detachable coil in experimental aneurysms

Yuichi Murayama*, Fernando Viñuela, Satoshi Tateshima, Nestor R. Gonzalez, Joon K. Song, Haleh Mahdavieh, Luisa Iruela-Arispe

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

67 Scopus citations


Background and Purpose - Acceleration of healing mechanisms is a promising approach to improve current limitations of endovascular aneurysm therapy with the use of platinum coils. We evaluated a new endovascular therapeutic, bioabsorbable polymeric material (BPM), which may promote cellular reaction in the aneurysms. Methods - Four different concentrations of lactide/glycolic acid copolymer [poly(D-L-lactic-co-glycolic acid)] (PLGA), 85/15, 75/25, 65/35, and 50/50, were used as BPMs. Sixteen experimental aneurysms were created in 8 swine. Eight-millimeter-long spiral-shaped BPMs were surgically implanted in the aneurysms without tight packing (n=3 for each BPM). Guglielmi detachable coils (GDCs) were used as control (n=4). The animals were killed 14 days after embolization, and angiographic, histological, and immunohistochemical analyses were performed. Results - Despite loose packing of aneurysms with BPMs, faster BPMs such as 50/50 or 65/35 PLGA demonstrated more mature collagen formation and fibrosis in the sac and neck of the aneurysm. One aneurysm treated with 65/35 PLGA, 1 treated with 75/25 PLGA, and all 3 treated with 85/15 PLGA showed a neck remnant on angiography. There was a linear relationship between collagen levels and polymer degradation properties (r=-0.9513). Conclusions - This preliminary animal study indicates that acceleration of aneurysm healing with the use of BPM is feasible. This concept can be applied to decrease and perhaps prevent aneurysmal recanalization after endovascular treatment of cerebral aneurysms.

Original languageEnglish (US)
Pages (from-to)1120-1128
Number of pages9
Issue number4
StatePublished - 2002


  • Animal models
  • Endovascular therapy
  • Intracranial aneurysm
  • Polymers
  • Tissue engineering

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

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