Central Adaptation following Brachial Plexus Injury

Neil G. Simon, Colin K. Franz, Nalin Gupta, Tord Alden, Michel Kliot*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


Brachial plexus trauma (BPT) often affects young patients and may result in lasting functional deficits. Standard care following BPT involves monitoring for clinical and electrophysiological evidence of muscle reinnervation, with surgical treatment decisions based on the presence or absence of spontaneous recovery. Data are emerging to suggest that central and peripheral adaptation may play a role in recovery following BPT. The present review highlights adaptive and maladaptive mechanisms of central and peripheral nervous system changes following BPT that may contribute to functional outcomes. Rehabilitation and other treatment strategies that harness or modulate these intrinsic adaptive mechanisms may improve functional outcomes following BPT.

Original languageEnglish (US)
Pages (from-to)325-332
Number of pages8
JournalWorld Neurosurgery
StatePublished - Jan 1 2016


  • Apraxia
  • Brachial plexus injury
  • Central adaptation
  • Nerve trauma
  • Neuroplasticity

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


Dive into the research topics of 'Central Adaptation following Brachial Plexus Injury'. Together they form a unique fingerprint.

Cite this