Central Core Fibers in an Acutely Psychotic Patient: Evidence for a Neurogenic Basis for the Muscle Abnormalities in the Acute Psychoses

Herbert Y. Meltzer*

*Corresponding author for this work

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

A 24-year-old black woman with probable manic-depressive illness was found to have central cores in all type I muscle fibers in a biopsy of the gastrocnemius muscle and in some type I fibers in a biopsy of the vastus lateralis muscle. Both biopsy specimens were differenteated into two main fiber types. The ultrastructural changes in the cores were more profound than in other cases of central core disease. Small atrophic fibers indicative of denervation or loss of the neurotrophic influence were also present. An electromyogram had both myopathic and neurogenic features. The question of whether the etiology of the muscle abnormalities in at least some acutely psychotic patients is neuropathic or myopathic, or a mixture of both, is discussed.

Original languageEnglish (US)
Pages (from-to)125-132
Number of pages8
JournalArchives of General Psychiatry
Volume27
Issue number1
DOIs
StatePublished - Jan 1 1972

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Psychotic Disorders
Biopsy
Muscles
Central Core Myopathy
Slow-Twitch Muscle Fibers
Quadriceps Muscle
Electromyography
Denervation
Skeletal Muscle
Psychosis
Fiber
Major Affective Disorder 2

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

Cite this

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