Abstract
Interferon regulatory factor 1 (IRF-1) is a transcription factor that has been implicated in the disease mechanisms of experimental autoimmune encephalomyelitis (EAE). In this study, we examined the role of central nervous system (CNS) expression of IRF-1 in the natural course of EAE. In an effort to dissect the CNS effects from the peripheral immune effects of IRF-1, we generated bone marrow chimera mice that differentially expressed IRF-1 in the CNS and in the immune system. We found that mice lacking IRF-1 in the CNS developed significantly milder clinical symptoms and shorter disease duration compared to those with wild-type background. Based on these results, we concluded that the CNS expression of IRF-1 regulates the disease process in EAE. Our findings are relevant to the inflammatory mechanisms involved in multiple sclerosis and may provide a basis for development of novel therapeutic targets of the disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 260-265 |
| Number of pages | 6 |
| Journal | Journal of Neuroimmune Pharmacology |
| Volume | 5 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 2010 |
Funding
Guarantor Kalipada Pahan, Ph.D., Rush University Medical Center, Department of Neurological Sciences, 1735 W. Harrison St, Suite 320, Chicago, IL 60612, USA, Tel: (312) 563-3592, Fax: (312) 563-3571, email: [email protected] Support This work was supported by grants from the National Institutes of Health, NIH K08 NS5040901 and the National Multiple Sclerosis Society RG4041A1/1 to Roumen Balabanov.
Keywords
- Central nervous system
- Experimental autoimmune encephalomyelitis
- Interferon regulatory factor 1
- Neuroimmunology
- Neuroinflammation
ASJC Scopus subject areas
- Neuroscience (miscellaneous)
- Immunology and Allergy
- Pharmacology
- Immunology