Central nervous system expression of interferon regulatory factor 1 regulates experimental autoimmune encephalomyelitis

Zhihua Ren, Yan Wang, Duan Tao, David Liebenson, Thomas Liggett, Rajendra Goswami, Dusan Stefoski, Roumen Balabanov*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Interferon regulatory factor 1 (IRF-1) is a transcription factor that has been implicated in the disease mechanisms of experimental autoimmune encephalomyelitis (EAE). In this study, we examined the role of central nervous system (CNS) expression of IRF-1 in the natural course of EAE. In an effort to dissect the CNS effects from the peripheral immune effects of IRF-1, we generated bone marrow chimera mice that differentially expressed IRF-1 in the CNS and in the immune system. We found that mice lacking IRF-1 in the CNS developed significantly milder clinical symptoms and shorter disease duration compared to those with wild-type background. Based on these results, we concluded that the CNS expression of IRF-1 regulates the disease process in EAE. Our findings are relevant to the inflammatory mechanisms involved in multiple sclerosis and may provide a basis for development of novel therapeutic targets of the disease.

Original languageEnglish (US)
Pages (from-to)260-265
Number of pages6
JournalJournal of Neuroimmune Pharmacology
Volume5
Issue number2
DOIs
StatePublished - Jun 1 2010

Keywords

  • Central nervous system
  • Experimental autoimmune encephalomyelitis
  • Interferon regulatory factor 1
  • Neuroimmunology
  • Neuroinflammation

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Immunology and Allergy
  • Immunology
  • Pharmacology

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