Central nervous system infections in cancer patients and hematopoietic stem cell transplant recipients

Michael J. Hoffman*, Valentina Stosor

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Central nervous system (CNS) infections in cancer patients present a diagnostic and therapeutic challenge for clinicians. While CNS infections are not frequent complications of cancer, its therapies, or hematopoietic stem cell transplantation, the importance of CNS infections lies in their propensity to result in profound morbidity and substantial mortality in this vulnerable patient population. With an expanding population of patients with malignant disease undergoing more potent and aggressive therapies and with the advent of newer immunomodulatory agents, the incidence of CNS infectious complications is likely to rise. This chapter will summarize the clinical and diagnostic evaluation of potential infections of the CNS in these patients and will discuss particular pathogens of interest with regard to this at-risk patient population.

Original languageEnglish (US)
Pages (from-to)253-298
Number of pages46
JournalCancer treatment and research
Volume161
DOIs
StatePublished - Jan 1 2014

Keywords

  • Antimicrobial resistance
  • Hematopoietic stem cell transplantation
  • Immunodeficiencies
  • Immunomodulatory agents
  • Meningitis
  • Neurologic abnormalities
  • Neutropenia
  • Norcardiosis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Central nervous system infections in cancer patients and hematopoietic stem cell transplant recipients'. Together they form a unique fingerprint.

  • Cite this