Central nervous system relapse following bone marrow transplantation in stage IV neuroblastoma

Susan Palasis*, Joan Morris, John C. Egelhoff

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Neuroblastoma is the most common extracranial solid tumor in pediatrics. The disease-free survival rate for patients with stage IV neuroblastoma has improved over the past 10 years secondary to more aggressive induction chemotherapy regimens combined with autologous bone marrow transplantation. The usual sites of recurrence include the site of primary tumor, residual gross disease, bone, and bone marrow. The central nervous system, a rare site of relapse, is being involved with increasing frequency. The authors report two cases of patients with treated stage IV neuroblastoma who had relapses isolated to the CNS.

Original languageEnglish (US)
Pages (from-to)443-452
Number of pages10
JournalPediatric Hematology and Oncology
Volume16
Issue number5
DOIs
StatePublished - Sep 1 1999

Keywords

  • Bone marrow transplantation
  • Central nervous system
  • Metastases
  • Neuroblastoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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