Central nervous system Sjögren's syndrome in a child: Case report and review of the literature

Jay A. Gottfried; Terri H. Finkel; Jill V. Hunter; David F. Carpentieri; Richard S. Finkel

doi:10.1177/088307380101600911

Central nervous system Sjögren's syndrome in a child: Case report and review of the literature

Jay A. Gottfried, Terri H. Finkel, Jill V. Hunter, David F. Carpentieri, Richard S. Finkel

Neurology

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

We describe a case of pediatric Sjögren's syndrome with progressive neurologic involvement. At age 4 years, she had been diagnosed with Melkersson-Rosenthal syndrome. After being stable with facial diplegia and swelling for 5 years, she acutely presented with diplopia, vertigo, and ataxia. Cranial magnetic resonance imaging (MRI) showed a left dorsal midbrain lesion. Serologic and histopathologic findings confirmed primary Sjögren's syndrome. She responded well to intravenous methylprednisolone, with subsequent clinical improvement and MRI resolution. This report reviews the pediatric literature and underscores the importance of considering Sjögren's syndrome in a child with unexplained facial weakness and in the differential diagnosis of pediatric stroke.

Original language	English (US)
Pages (from-to)	683-685
Number of pages	3
Journal	Journal of Child Neurology
Volume	16
Issue number	9
DOIs	https://doi.org/10.1177/088307380101600911
State	Published - Jan 1 2001

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Clinical Neurology

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title = "Central nervous system Sj{\"o}gren's syndrome in a child: Case report and review of the literature",

abstract = "We describe a case of pediatric Sj{\"o}gren's syndrome with progressive neurologic involvement. At age 4 years, she had been diagnosed with Melkersson-Rosenthal syndrome. After being stable with facial diplegia and swelling for 5 years, she acutely presented with diplopia, vertigo, and ataxia. Cranial magnetic resonance imaging (MRI) showed a left dorsal midbrain lesion. Serologic and histopathologic findings confirmed primary Sj{\"o}gren's syndrome. She responded well to intravenous methylprednisolone, with subsequent clinical improvement and MRI resolution. This report reviews the pediatric literature and underscores the importance of considering Sj{\"o}gren's syndrome in a child with unexplained facial weakness and in the differential diagnosis of pediatric stroke.",

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Central nervous system Sjögren's syndrome in a child: Case report and review of the literature

Abstract

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