Central physeal arrests as a manifestation of hypervitaminosis A

Matthew D. Saltzman, Erik C. King*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Vitamin A is necessary for synthesis of visual pigments and required in appropriate amounts for membrane stability. Acute hypervitamin A intoxication can lead to increased intracranial pressure, vomiting, and lethargy. Chronic excessive intake of vitamin A can lead to pruritis, muscle and bone tenderness, and failure to thrive. Reported effects of hypervitamin A intoxication on bone include osteoporosis, fracture, cortical thickening, and metaphyseal irregularity. We are reporting on a case of central physeal arrest in the distal femur, proximal tibia, and distal tibia after excessive intake of vitamin A.

Original languageEnglish (US)
Pages (from-to)351-353
Number of pages3
JournalJournal of Pediatric Orthopaedics
Issue number3
StatePublished - Apr 2007


  • Physeal arrest
  • Vitamin A

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Orthopedics and Sports Medicine


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