Central serous chorioretinopathy and phosphodiesterase-5 inhibitors: A case-control postmarketing surveillance study

Dustin D. French, Curtis E. Margo

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Purpose: The purpose of this study was to determine if there is an increased risk of central serous chorioretinopathy (CSC) associated with prescription exposure to phosphodiesterase-5 (PDE-5) inhibitors. Methods: A case-control study linking 2 National Veterans Health Administration databases (clinical and pharmacy) for fiscal years 2004 to 2005. The likelihood of past exposure to PDE-5 inhibitors among newly diagnosed patients with CSC, identified through International Classification of Diseases, 9th Edition, Clinical Modification codes, was compared with 2 age-matched control groups after excluding subjects with risk factors for CSC. Results: Among 577 men, aged 59 years and younger with newly diagnosed CSC during the study year, 111 were prescribed a PDE-5 inhibitor (19.2%). The proportions of age-matched controls prescribed a PDE-5 inhibitor in the 2 groups were 18.5% and 21.5%. The odds ratio of exposure was 1.05 (95% confidence limit: 0.74-1.22) and 0.87 (95% confidence limit: 0.68-1.12). Conclusion: Patients with CSC had no increase in prescription exposure to PDE-5 inhibitors than did age-matched control subjects. Although the findings in this study do not support an association between CSC and PDE-5 inhibitors, postmarketing surveillance methods for drug-related side effects have acknowledged limitations.

Original languageEnglish (US)
Pages (from-to)271-274
Number of pages4
Issue number2
StatePublished - Feb 2010


  • Case-control study
  • Central serous chorioretinopathy
  • Drug surveillance study
  • Drug-related side effect
  • Phosphodiesterase inhibitors
  • Sildenafil

ASJC Scopus subject areas

  • Ophthalmology


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