The Mis18 complex is a critical player in determining when and where centromeres are built. A new study identifies Polo-like kinase (Plk1) as a positive regulator required for the localization of Mis18 to centromeres. This is a critical step that is essential for proper centromere function and maintaining the integrity of the genome.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Agricultural and Biological Sciences(all)