Cerebellar Contributions to Social Cognition in ASD: A Predictive Processing Framework

Isabelle R. Frosch, Vijay A. Mittal, Anila M. D’Mello*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Functional, structural, and cytoarchitectural differences in the cerebellum are consistently reported in Autism Spectrum Disorders (ASD). Despite this, the mechanisms governing cerebellar contributions to ASD, particularly within the sociocognitive domain, are not well understood. Recently, it has been suggested that several core features of ASD may be associated with challenges creating and using prior expectations or predictions to rapidly adapt to changing stimuli or situations, also known as adaptive prediction. Importantly, neuroimaging, clinical, and animal work find that the cerebellum supports adaptive prediction in both motor and non-motor domains. Perturbations to the cerebellum via injury or neuromodulation have been associated with impairments in predictive skills. Here, we review evidence for a cerebellar role in social cognition and adaptive prediction across individuals with and without ASD.

Original languageEnglish (US)
Article number810425
JournalFrontiers in Integrative Neuroscience
Volume16
DOIs
StatePublished - Jan 28 2022

Keywords

  • action perception
  • adaptive prediction
  • autism spectrum disorder (ASD)
  • cerebellum
  • language
  • neuroimaging
  • predictive processing
  • social cognition

ASJC Scopus subject areas

  • Sensory Systems
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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