Cerebral amyloid angiopathy-related intracranial hemorrhage

Lesli E. Skolarus, Teresa L. Jacobs

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The most common risk factors associated with intracerebral hemorrhage (ICH) are hypertension and cerebral amyloid angiopathy (CAA). It is characterized by the deposition of beta-amyloid peptide into the media and adventitia of small arteries and capillaries. The beta-amyloid peptide is toxic to the vascular smooth muscle cells leading to damage to the blood vessel wall and consequent hemorrhage. The diagnosis is based on the Boston Criteria utilizing clinical data, autopsy, surgical pathology, or magnetic resonance imaging (MRI). Medical treatment of CAA-related ICH is based on control of the hemorrhage, management of blood pressure, management of elevated ICP, and treatment of seizures, fevers, and hyperglycemia. The management of CAA-related ICH is complex and close neurologic monitoring is essential. With the development of new potential biomarkers for the disease, we may begin to explore therapeutic options before patients develop ICH.

Original languageEnglish (US)
Title of host publicationCase Studies in Neuroanesthesia and Neurocritical Care
PublisherCambridge University Press
Pages295-298
Number of pages4
ISBN (Electronic)9780511997426
ISBN (Print)9780521193801
DOIs
StatePublished - Jan 1 2011

Keywords

  • Beta-amyloid peptide
  • Biomarkers
  • Cerebral amyloid angiopathy
  • Hypertension
  • Intracerebral hemorrhage
  • MRI

ASJC Scopus subject areas

  • General Medicine

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