Abstract
The most common risk factors associated with intracerebral hemorrhage (ICH) are hypertension and cerebral amyloid angiopathy (CAA). It is characterized by the deposition of beta-amyloid peptide into the media and adventitia of small arteries and capillaries. The beta-amyloid peptide is toxic to the vascular smooth muscle cells leading to damage to the blood vessel wall and consequent hemorrhage. The diagnosis is based on the Boston Criteria utilizing clinical data, autopsy, surgical pathology, or magnetic resonance imaging (MRI). Medical treatment of CAA-related ICH is based on control of the hemorrhage, management of blood pressure, management of elevated ICP, and treatment of seizures, fevers, and hyperglycemia. The management of CAA-related ICH is complex and close neurologic monitoring is essential. With the development of new potential biomarkers for the disease, we may begin to explore therapeutic options before patients develop ICH.
Original language | English (US) |
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Title of host publication | Case Studies in Neuroanesthesia and Neurocritical Care |
Publisher | Cambridge University Press |
Pages | 295-298 |
Number of pages | 4 |
ISBN (Electronic) | 9780511997426 |
ISBN (Print) | 9780521193801 |
DOIs | |
State | Published - Jan 1 2011 |
Keywords
- Beta-amyloid peptide
- Biomarkers
- Cerebral amyloid angiopathy
- Hypertension
- Intracerebral hemorrhage
- MRI
ASJC Scopus subject areas
- General Medicine