Cerebral blood flow in systemic lupus erythematosus with or without cerebral complications

M. J. Kushner; J. Chawluk; F. Fazekas; B. Mandell; A. Burke; J. Jaggi; M. Rosen; M. Reivich

doi:10.1212/wnl.37.10.1596

Cerebral blood flow in systemic lupus erythematosus with or without cerebral complications

M. J. Kushner^*, J. Chawluk, F. Fazekas, B. Mandell, A. Burke, J. Jaggi, M. Rosen, M. Reivich

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

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Abstract

We measured mean cerebral blood flow (CBF) in 25 lupus patients using the xenon-133 method. The CBF was normal in lupus patients without cerebral disease and also in CNS lupus patients in remission. The CBF was lower than normal during bouts of cerebral lupus (p < 0.001). Repeat studies showed a stereotyped pattern consisting of depressed CBF during exacerbation of CNS disease and normalization of CBF during remission (p < 0.01). These results show that CBF is a sensitive indicator of activity of CNS disease and that the direction of change in CBF reflects the clinical course of CNS lupus.

Original language	English (US)
Pages (from-to)	1596-1598
Number of pages	3
Journal	Neurology
Volume	37
Issue number	10
DOIs	https://doi.org/10.1212/wnl.37.10.1596
State	Published - Oct 1987

ASJC Scopus subject areas

Clinical Neurology

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10.1212/wnl.37.10.1596

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abstract = "We measured mean cerebral blood flow (CBF) in 25 lupus patients using the xenon-133 method. The CBF was normal in lupus patients without cerebral disease and also in CNS lupus patients in remission. The CBF was lower than normal during bouts of cerebral lupus (p < 0.001). Repeat studies showed a stereotyped pattern consisting of depressed CBF during exacerbation of CNS disease and normalization of CBF during remission (p < 0.01). These results show that CBF is a sensitive indicator of activity of CNS disease and that the direction of change in CBF reflects the clinical course of CNS lupus.",

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AU - Kushner, M. J.

AU - Chawluk, J.

AU - Fazekas, F.

AU - Mandell, B.

AU - Burke, A.

AU - Jaggi, J.

AU - Rosen, M.

AU - Reivich, M.

PY - 1987/10

Y1 - 1987/10

N2 - We measured mean cerebral blood flow (CBF) in 25 lupus patients using the xenon-133 method. The CBF was normal in lupus patients without cerebral disease and also in CNS lupus patients in remission. The CBF was lower than normal during bouts of cerebral lupus (p < 0.001). Repeat studies showed a stereotyped pattern consisting of depressed CBF during exacerbation of CNS disease and normalization of CBF during remission (p < 0.01). These results show that CBF is a sensitive indicator of activity of CNS disease and that the direction of change in CBF reflects the clinical course of CNS lupus.

AB - We measured mean cerebral blood flow (CBF) in 25 lupus patients using the xenon-133 method. The CBF was normal in lupus patients without cerebral disease and also in CNS lupus patients in remission. The CBF was lower than normal during bouts of cerebral lupus (p < 0.001). Repeat studies showed a stereotyped pattern consisting of depressed CBF during exacerbation of CNS disease and normalization of CBF during remission (p < 0.01). These results show that CBF is a sensitive indicator of activity of CNS disease and that the direction of change in CBF reflects the clinical course of CNS lupus.

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Cerebral blood flow in systemic lupus erythematosus with or without cerebral complications

Abstract

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