Cerebral blood flow in systemic lupus erythematosus with or without cerebral complications

M. J. Kushner*, J. Chawluk, F. Fazekas, B. Mandell, A. Burke, J. Jaggi, M. Rosen, M. Reivich

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

We measured mean cerebral blood flow (CBF) in 25 lupus patients using the xenon-133 method. The CBF was normal in lupus patients without cerebral disease and also in CNS lupus patients in remission. The CBF was lower than normal during bouts of cerebral lupus (p < 0.001). Repeat studies showed a stereotyped pattern consisting of depressed CBF during exacerbation of CNS disease and normalization of CBF during remission (p < 0.01). These results show that CBF is a sensitive indicator of activity of CNS disease and that the direction of change in CBF reflects the clinical course of CNS lupus.

Original languageEnglish (US)
Pages (from-to)1596-1598
Number of pages3
JournalNeurology
Volume37
Issue number10
DOIs
StatePublished - Oct 1987

ASJC Scopus subject areas

  • Clinical Neurology

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