Cerebral diaschisis in patients with malignant glioma

Jack M. Rozental*, Ross L. Levine, Robert J. Nickles, Jeffrey A. Dobkin, Joan M. Hanson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

A positron emission tomography study using [18F]-fluorodeoxyglucose was undertaken to identify and quantitate whether diaschisis occurred in cerebral cortex, basal ganglia, or thalamus, as well as in cerebellar cortex and dentate nuclei in patients with malignant glioma. The relationship between diaschisis in these cerebral structures and clinically significant hemiparesis in patients was analysed. A 30% decrease in the regional metabolic rate for glucose in the cerebellar hemisphere contralateral to the tumor, and ipsilateral to the motor deficit, was identified and was statistically significant (p > 0.001). Decreased metabolism in the cerebellar hemisphere contralateral to the tumor was not seen in patients without hemiparesis. Parietal lobes affected by tumor had a larger decrease in metabolism than did frontal lobes with tumor (p > 0.01). The overall metabolism of the unaffected cerebellar hemisphere, relative to the peak metabolic activity of the brain, was not depressed in patients with tumor. In addition, the activity of subcortical nuclei was relatively unaffected by adjacent tumor or motor deficit.

Original languageEnglish (US)
Pages (from-to)153-161
Number of pages9
JournalJournal of Neuro-Oncology
Volume8
Issue number2
DOIs
StatePublished - Apr 1990

Keywords

  • PET scan
  • basal ganglia
  • cerebellum
  • diaschisis
  • malignant glioma

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

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