Cerebral ischemia-reperfusion injury in the gerbil

Anita Patt; Robert B. Rutherford; William H. Pearce; John E. Repine

doi:10.1016/0022-4804(87)90019-9

Cerebral ischemia-reperfusion injury in the gerbil

Anita Patt^*, Robert B. Rutherford, William H. Pearce, John E. Repine

^*Corresponding author for this work

Surgery, Vascular Surgery Division

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Gerbils subjected to cerebral ischemia (unilateral carotid occlusion for 6 hr) were either asymptomatic or developed increasingly severe neurologic deficits which correlated with degrees of brain swelling (weights of ischemic hemisphere versus the contralateral control hemispheres) following 3 hr of reperfusion. Asymptomatic gerbils or gerbils suffering only mild deficits survived for 1 week following reperfusion while gerbils suffering moderate to severe deficits had a poor survival rate with only 22% remaining alive after 1 week.

Original language	English (US)
Pages (from-to)	462-466
Number of pages	5
Journal	Journal of Surgical Research
Volume	42
Issue number	5
DOIs	https://doi.org/10.1016/0022-4804(87)90019-9
State	Published - May 1987

ASJC Scopus subject areas

Surgery

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10.1016/0022-4804(87)90019-9

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@article{17d79018af204244937e8e6d11356581,

title = "Cerebral ischemia-reperfusion injury in the gerbil",

abstract = "Gerbils subjected to cerebral ischemia (unilateral carotid occlusion for 6 hr) were either asymptomatic or developed increasingly severe neurologic deficits which correlated with degrees of brain swelling (weights of ischemic hemisphere versus the contralateral control hemispheres) following 3 hr of reperfusion. Asymptomatic gerbils or gerbils suffering only mild deficits survived for 1 week following reperfusion while gerbils suffering moderate to severe deficits had a poor survival rate with only 22% remaining alive after 1 week.",

author = "Anita Patt and Rutherford, {Robert B.} and Pearce, {William H.} and Repine, {John E.}",

note = "Funding Information: This work was supportedi n part by grantsf rom the National Instituteso f Health, American Heart Association, Council for Tobacco Research, and the Swan Foundation.T he authorsa cknowledgeth e excellenta s-sistance of Jacqueline Borenstein in preparing this manuscripta nd the constructivea dvice and supporto f Dr. Alden H. Harken.",

year = "1987",

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doi = "10.1016/0022-4804(87)90019-9",

language = "English (US)",

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journal = "Journal of Surgical Research",

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T1 - Cerebral ischemia-reperfusion injury in the gerbil

AU - Patt, Anita

AU - Rutherford, Robert B.

AU - Pearce, William H.

AU - Repine, John E.

N1 - Funding Information: This work was supportedi n part by grantsf rom the National Instituteso f Health, American Heart Association, Council for Tobacco Research, and the Swan Foundation.T he authorsa cknowledgeth e excellenta s-sistance of Jacqueline Borenstein in preparing this manuscripta nd the constructivea dvice and supporto f Dr. Alden H. Harken.

PY - 1987/5

Y1 - 1987/5

N2 - Gerbils subjected to cerebral ischemia (unilateral carotid occlusion for 6 hr) were either asymptomatic or developed increasingly severe neurologic deficits which correlated with degrees of brain swelling (weights of ischemic hemisphere versus the contralateral control hemispheres) following 3 hr of reperfusion. Asymptomatic gerbils or gerbils suffering only mild deficits survived for 1 week following reperfusion while gerbils suffering moderate to severe deficits had a poor survival rate with only 22% remaining alive after 1 week.

AB - Gerbils subjected to cerebral ischemia (unilateral carotid occlusion for 6 hr) were either asymptomatic or developed increasingly severe neurologic deficits which correlated with degrees of brain swelling (weights of ischemic hemisphere versus the contralateral control hemispheres) following 3 hr of reperfusion. Asymptomatic gerbils or gerbils suffering only mild deficits survived for 1 week following reperfusion while gerbils suffering moderate to severe deficits had a poor survival rate with only 22% remaining alive after 1 week.

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JO - Journal of Surgical Research

JF - Journal of Surgical Research

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ER -

Cerebral ischemia-reperfusion injury in the gerbil

Abstract

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