Cerebral ischemia-reperfusion injury in the gerbil

Anita Patt*, Robert B. Rutherford, William H. Pearce, John E. Repine

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Gerbils subjected to cerebral ischemia (unilateral carotid occlusion for 6 hr) were either asymptomatic or developed increasingly severe neurologic deficits which correlated with degrees of brain swelling (weights of ischemic hemisphere versus the contralateral control hemispheres) following 3 hr of reperfusion. Asymptomatic gerbils or gerbils suffering only mild deficits survived for 1 week following reperfusion while gerbils suffering moderate to severe deficits had a poor survival rate with only 22% remaining alive after 1 week.

Original languageEnglish (US)
Pages (from-to)462-466
Number of pages5
JournalJournal of Surgical Research
Volume42
Issue number5
DOIs
StatePublished - May 1987

ASJC Scopus subject areas

  • Surgery

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