Cerebrospinal fluid pathways in a murine mutant.

D. G. McLone*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


The hy-3/hy-3 mouse is a model of congenital hydrocephalus. The development of the subarachnoid space and extracellular space were studied in normal and hydrocephalic animals. A previous space in the mesenchyme is altered to form the subarachnoid space. Changes in the extracellular space demonstrate that this space is dynamic and acts to compensate for events occurring in the ventricular system. The aqueduct and central spinal canal are also involved in the hydrocephalic process. Change in cerebral vasculature may indicate the processes which lead to irreversibility.

Original languageEnglish (US)
Pages (from-to)293-303
Number of pages11
JournalChild's Brain
Issue number3
StatePublished - Jan 1 1979

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neuroscience(all)


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