Cerebrospinal fluid profile of amyloid β42 (Aβ42), hTau and ubiquitin in North Indian Alzheimer's disease patients

Ramesh J.L. Kandimalla, Prabhakar S, Binukumar BK, Willayat Yousuf Wani, Deep Raj Sharma, V. K. Grover, Neerja Bhardwaj, Kajal Jain, Kiran Dip Gill*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Alzheimer's disease (AD) is the most common form of dementia, and is characterized by the degeneration of neurons and their synapses, and a higher number of amyloid plaques and neurofibrillary tangles (NFTs) compared with that found in non-demented individuals. Amyloid-β-peptides (Aβ) are major components of amyloid plaques in AD brain whereas NFTs are composed of Tau and associated with ubiquitin. The aim of the present study was to analyze the levels of Aβ42, hTau (total Tau) and ubiquitin in CSF of North Indian population. CSF Aβ42, Tau and ubiquitin were measured in CSF of AD patients as well as controls using ELISA assays. Here we report low Aβ42 levels in AD patients (324.24. ±. 76.38. pg/ml) as compared to those in non-AD (NAD) (668.34. ±. 43.13. pg/ml), neurological controls (NCs) (727.28. ±. 46.49. pg/ml) and healthy controls (HCs) (976.47. ±. 124.46. pg/ml). In contrast, hTau and ubiquitin levels were significantly high (568.65. ±. 48.89. pg/ml and 36.82. ±. 4.34. ng/ml, respectively) in AD patients compared to those in NAD, NC and HC. The hTau levels were 267.37. ±. 36.64. pg/ml, 167.34. ±. 44.27. pg/ml and 107.62. ±. 24.27. pg/ml in NAD, NC and HC, respectively. Similarly, ubiquitin levels were 23.57. ±. 2.32. ng/ml, 19.76. ±. 3.64. ng/ml and 13.24. ±. 4.56. ng/ml in NAD, NC and HC, respectively. In conclusion, low Aβ42 and high Tau-ubiquitin levels were found in North Indian AD patients.

Original languageEnglish (US)
Pages (from-to)134-138
Number of pages5
JournalNeuroscience Letters
Volume487
Issue number2
DOIs
StatePublished - Jan 7 2011

Keywords

  • Aβ42
  • Alzheimer's disease
  • HTau
  • North Indian population
  • Ubiquitin

ASJC Scopus subject areas

  • General Neuroscience

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