Cerebrovascular and mitochondrial abnormalities in Alzheimer’s disease: a brief overview

Cristina Carvalho; Sónia C. Correia; George Perry; Rudy J. Castellani; Paula I. Moreira

doi:10.1007/s00702-015-1367-7

Cerebrovascular and mitochondrial abnormalities in Alzheimer’s disease: a brief overview

Cristina Carvalho, Sónia C. Correia, George Perry, Rudy J. Castellani, Paula I. Moreira^*

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

Multiple lines of evidence suggest that vascular alterations contribute to Alzheimer’s disease (AD) pathogenesis. It is also well established that mitochondrial abnormalities occur early in course of AD. Here, we give an overview of the vascular and mitochondrial abnormalities occurring in AD, including mitochondrial alterations in vascular endothelial cells within the brain, which is emerging as a common feature that bridges cerebral vasculature and mitochondrial metabolism.

Original language	English (US)
Pages (from-to)	107-111
Number of pages	5
Journal	Journal of Neural Transmission
Volume	123
Issue number	2
DOIs	https://doi.org/10.1007/s00702-015-1367-7
State	Published - Feb 1 2016

Funding

The authors' work is supported by Quadro de ReferÃªncia EstratÃ©gico Nacional (QREN DO-IT) and Alzheimer's Association (NIRG-13-282387), by the Semmes Foundation, and by a grant from the National Institute on Minority Health and Health Disparities (G12MD007591) from the National Institutes of Health.

Keywords

Alzheimer’s disease
Brain vasculature
Mitochondria
Oxidative stress

ASJC Scopus subject areas

Clinical Neurology
Neurology
Psychiatry and Mental health
Biological Psychiatry

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10.1007/s00702-015-1367-7

Cite this

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title = "Cerebrovascular and mitochondrial abnormalities in Alzheimer{\textquoteright}s disease: a brief overview",

abstract = "Multiple lines of evidence suggest that vascular alterations contribute to Alzheimer{\textquoteright}s disease (AD) pathogenesis. It is also well established that mitochondrial abnormalities occur early in course of AD. Here, we give an overview of the vascular and mitochondrial abnormalities occurring in AD, including mitochondrial alterations in vascular endothelial cells within the brain, which is emerging as a common feature that bridges cerebral vasculature and mitochondrial metabolism.",

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AU - Correia, Sónia C.

AU - Perry, George

AU - Castellani, Rudy J.

AU - Moreira, Paula I.

PY - 2016/2/1

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N2 - Multiple lines of evidence suggest that vascular alterations contribute to Alzheimer’s disease (AD) pathogenesis. It is also well established that mitochondrial abnormalities occur early in course of AD. Here, we give an overview of the vascular and mitochondrial abnormalities occurring in AD, including mitochondrial alterations in vascular endothelial cells within the brain, which is emerging as a common feature that bridges cerebral vasculature and mitochondrial metabolism.

AB - Multiple lines of evidence suggest that vascular alterations contribute to Alzheimer’s disease (AD) pathogenesis. It is also well established that mitochondrial abnormalities occur early in course of AD. Here, we give an overview of the vascular and mitochondrial abnormalities occurring in AD, including mitochondrial alterations in vascular endothelial cells within the brain, which is emerging as a common feature that bridges cerebral vasculature and mitochondrial metabolism.

KW - Alzheimer’s disease

KW - Brain vasculature

KW - Mitochondria

KW - Oxidative stress

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Cerebrovascular and mitochondrial abnormalities in Alzheimer’s disease: a brief overview

Abstract

Funding

Keywords

ASJC Scopus subject areas

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