Cerebrovascular and mitochondrial abnormalities in Alzheimer’s disease: a brief overview

Cristina Carvalho, Sónia C. Correia, George Perry, Rudy J. Castellani, Paula I. Moreira*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

Multiple lines of evidence suggest that vascular alterations contribute to Alzheimer’s disease (AD) pathogenesis. It is also well established that mitochondrial abnormalities occur early in course of AD. Here, we give an overview of the vascular and mitochondrial abnormalities occurring in AD, including mitochondrial alterations in vascular endothelial cells within the brain, which is emerging as a common feature that bridges cerebral vasculature and mitochondrial metabolism.

Original languageEnglish (US)
Pages (from-to)107-111
Number of pages5
JournalJournal of Neural Transmission
Volume123
Issue number2
DOIs
StatePublished - Feb 1 2016
Externally publishedYes

Keywords

  • Alzheimer’s disease
  • Brain vasculature
  • Mitochondria
  • Oxidative stress

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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