Abstract
Multiple lines of evidence suggest that vascular alterations contribute to Alzheimer’s disease (AD) pathogenesis. It is also well established that mitochondrial abnormalities occur early in course of AD. Here, we give an overview of the vascular and mitochondrial abnormalities occurring in AD, including mitochondrial alterations in vascular endothelial cells within the brain, which is emerging as a common feature that bridges cerebral vasculature and mitochondrial metabolism.
Original language | English (US) |
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Pages (from-to) | 107-111 |
Number of pages | 5 |
Journal | Journal of Neural Transmission |
Volume | 123 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1 2016 |
Funding
The authors' work is supported by Quadro de Referência Estratégico Nacional (QREN DO-IT) and Alzheimer's Association (NIRG-13-282387), by the Semmes Foundation, and by a grant from the National Institute on Minority Health and Health Disparities (G12MD007591) from the National Institutes of Health.
Keywords
- Alzheimer’s disease
- Brain vasculature
- Mitochondria
- Oxidative stress
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
- Psychiatry and Mental health
- Biological Psychiatry