TY - JOUR
T1 - Cervical cancer vaccines
T2 - Recent advances in HPV research
AU - Eiben, Gretchen L.
AU - Da Silva, Diane M.
AU - Fausch, Steven C.
AU - Le Poole, I. Caroline
AU - Nishimura, Michael I.
AU - Kast, W. Martin
PY - 2003
Y1 - 2003
N2 - Carcinomas of the anogenital tract, particularly cancer of the cervix, account for almost 12% of all cancers in women, and so represent the second most frequent gynecological malignancy in the world (48). It is well established that chronic infection of cervical epithelium by human papillomaviruses (HPV) is necessary for the development of cervical cancer. In fact, HPV DNA has been demonstrated in more than 99.7% of cervical cancer biopsy specimens, with high-risk HPV16 and HPV18 sequences being most prevalent (45,73). Therefore, an effective vaccine that would mount an immune response against HPV-related proteins might contribute to the prevention or elimination of HPV expressing lesions. This review will concentrate on the most recent advances in vaccine-mediated prevention and immunotherapy of HPV-induced cervical cancer, including presentations from the 20th International HPV Conference held in October 2002 in Paris.
AB - Carcinomas of the anogenital tract, particularly cancer of the cervix, account for almost 12% of all cancers in women, and so represent the second most frequent gynecological malignancy in the world (48). It is well established that chronic infection of cervical epithelium by human papillomaviruses (HPV) is necessary for the development of cervical cancer. In fact, HPV DNA has been demonstrated in more than 99.7% of cervical cancer biopsy specimens, with high-risk HPV16 and HPV18 sequences being most prevalent (45,73). Therefore, an effective vaccine that would mount an immune response against HPV-related proteins might contribute to the prevention or elimination of HPV expressing lesions. This review will concentrate on the most recent advances in vaccine-mediated prevention and immunotherapy of HPV-induced cervical cancer, including presentations from the 20th International HPV Conference held in October 2002 in Paris.
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U2 - 10.1089/088282403322017866
DO - 10.1089/088282403322017866
M3 - Review article
C2 - 12828864
AN - SCOPUS:0038043426
SN - 0882-8245
VL - 16
SP - 111
EP - 121
JO - Viral Immunology
JF - Viral Immunology
IS - 2
ER -
