TY - JOUR
T1 - Cesium prevents maintenance of long-term depression in rat hippocampal CA1 neurons
AU - Maccaferri, Gianmaria
AU - Janigro, Damir
AU - Lazzari, Alberto
AU - DiFrancesco, Dario
PY - 1994/9
Y1 - 1994/9
N2 - Long-term depression of field excitatory postsynaptic potentials (EPSP) in the CA1 region of hippocampal slices was evoked by delivering a 15 min train of pulses at 1 Hz to the Schaffer-commissural-CAl pathway, and prevented by adding an Af-methyl-D-aspartate (NMDA) receptor antagonist (AP-5,50 μM) to the perfusing medium. Superfusion of the slices with Cs (2 mM) during the 1 Hz stimulation period could both inhibit the maintenance phase of the depression itself and elicit spontaneous rhythmic activity. Cs had no effect on the postsynaptic response to the GAB A-B agonist, baclofen. As a major effect of Cs is a block of the hyperpolarization-activated current (Ih), these results suggest the possible involvement of Ih in the maintenance of long-term depression.
AB - Long-term depression of field excitatory postsynaptic potentials (EPSP) in the CA1 region of hippocampal slices was evoked by delivering a 15 min train of pulses at 1 Hz to the Schaffer-commissural-CAl pathway, and prevented by adding an Af-methyl-D-aspartate (NMDA) receptor antagonist (AP-5,50 μM) to the perfusing medium. Superfusion of the slices with Cs (2 mM) during the 1 Hz stimulation period could both inhibit the maintenance phase of the depression itself and elicit spontaneous rhythmic activity. Cs had no effect on the postsynaptic response to the GAB A-B agonist, baclofen. As a major effect of Cs is a block of the hyperpolarization-activated current (Ih), these results suggest the possible involvement of Ih in the maintenance of long-term depression.
KW - Hippocampus
KW - Hyperpolarization-activated current
KW - Long-term depression
KW - NMDA-receptor
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U2 - 10.1097/00001756-199409080-00032
DO - 10.1097/00001756-199409080-00032
M3 - Article
C2 - 7827339
AN - SCOPUS:0027981304
SN - 0959-4965
VL - 5
SP - 1813
EP - 1816
JO - Neuroreport
JF - Neuroreport
IS - 14
ER -