Cesium prevents maintenance of long-term depression in rat hippocampal CA1 neurons

Gianmaria Maccaferri*, Damir Janigro, Alberto Lazzari, Dario DiFrancesco

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Long-term depression of field excitatory postsynaptic potentials (EPSP) in the CA1 region of hippocampal slices was evoked by delivering a 15 min train of pulses at 1 Hz to the Schaffer-commissural-CAl pathway, and prevented by adding an Af-methyl-D-aspartate (NMDA) receptor antagonist (AP-5,50 μM) to the perfusing medium. Superfusion of the slices with Cs (2 mM) during the 1 Hz stimulation period could both inhibit the maintenance phase of the depression itself and elicit spontaneous rhythmic activity. Cs had no effect on the postsynaptic response to the GAB A-B agonist, baclofen. As a major effect of Cs is a block of the hyperpolarization-activated current (Ih), these results suggest the possible involvement of Ih in the maintenance of long-term depression.

Original languageEnglish (US)
Pages (from-to)1813-1816
Number of pages4
JournalNeuroreport
Volume5
Issue number14
DOIs
StatePublished - Sep 1994

Keywords

  • Hippocampus
  • Hyperpolarization-activated current
  • Long-term depression
  • NMDA-receptor

ASJC Scopus subject areas

  • Neuroscience(all)

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