Challenges and controversies concerning neisseria gonorrhoeae-neutrophil interactions in pathogenesis

Alison K. Criss, Caroline A. Genco, Scott D. Gray-Owen, Ann E. Jerse, H. Steven Seifert

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The bacterium Neisseria gonorrhoeae (Ngo) is the main cause of the sexu-ally transmitted infection gonorrhea. The global incidence of 87 million new Ngo infections each year, rising infection rates, and the emergence of Ngo strains that are resistant to all clinically recommended antibiotics have raised the specter of untreatable infections (M. Unemo, H. S. Seifert, E. W. Hook, III, S. Hawkes, et al., Nat Rev Dis Primers 5:79, 2019, https://doi.org/10.1038/s41572-019-0128-6). Given their abundance in symp-tomatic disease, neutrophils are central to both Ngo infection and consequent damage to host tissues. This article highlights present knowledge and the main open questions about Ngo-neutrophil interactions in immunity versus disease pathogenesis.

Original languageEnglish (US)
Article numbere00721-21
JournalmBio
Volume12
Issue number3
DOIs
StatePublished - 2021

Keywords

  • Gonorrhea
  • Neisseria gonorrhoeae
  • Neutrophils

ASJC Scopus subject areas

  • Microbiology
  • Virology

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