TY - JOUR
T1 - Challenges and opportunities for pediatric severe TBI—review of the evidence and exploring a way forward
AU - for the Investigators of the ADAPT Study
AU - Bell, Michael J.
AU - Adelson, P. David
AU - Wisniewski, Stephen R.
AU - Agrawal, Shruti
AU - Mahoney, Sarah
AU - Gupta, Deepak
AU - Beca, John
AU - Loftis, Laura
AU - Morris, Kevin
AU - Piper, Lauren
AU - Slater, Anthony
AU - Walson, Karen
AU - Bennett, Tellen
AU - Kilbaugh, Todd
AU - O’Meara, A. M.Iqbal
AU - Dean, Nathan
AU - Chima, Ranjit S.
AU - Biagas, Katherine
AU - Wildschut, Enno
AU - Peters, Mark
AU - LaRovere, Kerri
AU - Balcells, Joan
AU - Robertson, Courtney
AU - Gertz, Shira
AU - Deep, Akash
AU - Cooper, Sian
AU - Wainwright, Mark
AU - Murphy, Sarah
AU - Kuluz, John
AU - Butt, Warwick
AU - O’Brien, Nicole
AU - Thomas, Neal J.
AU - Buttram, Sandra
AU - Erickson, Simon
AU - Samuel, J. Mahil
AU - Agbeko, Rachel
AU - Edwards, Richard
AU - Ramakrishnan, Kesava Ananth
AU - Winkler, Margaret
AU - Borasino, Santiago
AU - Natale, Joanne
AU - Giza, Christopher
AU - Hilfiker, Mary
AU - Shellington, David
AU - Figaji, Anthony
AU - Newell, Elizabeth
AU - Truemper, Edward
AU - Clark, Robert
AU - Newth, Kit
AU - Shafi, Nadeem
N1 - Funding Information:
Conflict of interest The authors have no conflicts of interest to report except for the grant funding from NIH.
Funding Information:
Funding Research reported in this publication was supported by the National Institute of Neurological Disorders and Stroke of the National Institutes of Health under Award Number U01 NS081041. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Publisher Copyright:
© 2017, Springer-Verlag GmbH Germany.
PY - 2017/10/1
Y1 - 2017/10/1
N2 - Traumatic brain injury (TBI) is a leading killer of children in the developed and developing world. Despite evidence-based guidelines and several recent clinical trials, the progress in developing best practices for children with severe TBI has been slow. This article describes (i) the burden of the disease, (ii) the inadequacies of the evidence-based guidelines, (iii) the failure of the largest clinical trials to prove their primary hypotheses, and (iv) possible advances from an observational cohort study called the Approaches and Decisions for Acute Pediatric TBI (ADAPT) Trial that has recently completed enrollment.
AB - Traumatic brain injury (TBI) is a leading killer of children in the developed and developing world. Despite evidence-based guidelines and several recent clinical trials, the progress in developing best practices for children with severe TBI has been slow. This article describes (i) the burden of the disease, (ii) the inadequacies of the evidence-based guidelines, (iii) the failure of the largest clinical trials to prove their primary hypotheses, and (iv) possible advances from an observational cohort study called the Approaches and Decisions for Acute Pediatric TBI (ADAPT) Trial that has recently completed enrollment.
KW - Children
KW - Comparative effectiveness research
KW - Evidenced-based guidelines
KW - Pediatric neurocritical care
KW - Pediatric neurotrauma
KW - Severe traumatic brain injury
UR - http://www.scopus.com/inward/record.url?scp=85029150855&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85029150855&partnerID=8YFLogxK
U2 - 10.1007/s00381-017-3530-y
DO - 10.1007/s00381-017-3530-y
M3 - Article
C2 - 29149394
AN - SCOPUS:85029150855
SN - 0256-7040
VL - 33
SP - 1663
EP - 1667
JO - Child's Nervous System
JF - Child's Nervous System
IS - 10
ER -