Challenges in diagnosis of primary progressive aphasia

Ellen C. Clarke*, Borna Bonakdarpour

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Two 68-year-old men presented to the behavioral neurology clinic with memory complaints. The clinical picture was complicated by bilingualism and psychiatric comorbidities. Based on a combination of cognitive and language testing, 5-fluorodeoxyglucose positron emission tomography (FDG-PET), and/or magnetic resonance imaging (MRI) of the brain, both cases were initially diagnosed as having mild cognitive impairment (MCI). At follow-up, however, both cases' language profiles and neuroimaging had evolved to clearly indicate primary progressive aphasia (PPA) as the underlying condition rather than MCI. These cases underscore the importance of careful observation of clinical and neuroimaging data over time to reach an accurate diagnosis.

Original languageEnglish (US)
Article numbere230630
JournalBMJ case reports
Issue number11
StatePublished - Nov 1 2019


  • dementia, Alzheimer's type
  • memory disorders
  • neuroimaging
  • neurology
  • radiology

ASJC Scopus subject areas

  • Medicine(all)

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