TY - JOUR
T1 - Challenges in drug delivery to tumors of the central nervous system
T2 - An overview of pharmacological and surgical considerations
AU - Serwer, Laura P.
AU - James, C. David
PY - 2012/5/15
Y1 - 2012/5/15
N2 - The majority of newly diagnosed brain tumors are treated with surgery, radiation, and the chemotherapeutic temozolomide. Development of additional therapeutics to improve treatment outcomes is complicated by the blood-brain barrier (BBB), which acts to protect healthy tissue from chemical insults. The high pressure found within brain tumors adds a challenge to local delivery of therapy by limiting the distribution of bolus injections. Here we discuss various drug delivery strategies, including convection-enhanced delivery, intranasal delivery, and intrathecal delivery, as well as pharmacological strategies for improving therapeutic efficacy, such as blood-brain barrier disruption.
AB - The majority of newly diagnosed brain tumors are treated with surgery, radiation, and the chemotherapeutic temozolomide. Development of additional therapeutics to improve treatment outcomes is complicated by the blood-brain barrier (BBB), which acts to protect healthy tissue from chemical insults. The high pressure found within brain tumors adds a challenge to local delivery of therapy by limiting the distribution of bolus injections. Here we discuss various drug delivery strategies, including convection-enhanced delivery, intranasal delivery, and intrathecal delivery, as well as pharmacological strategies for improving therapeutic efficacy, such as blood-brain barrier disruption.
KW - CED
KW - Chemotherapy
KW - Convection-enhanced delivery
KW - Glioblastoma
KW - Glioma
KW - Intranasal
KW - Intrathecal
KW - Liposome
UR - http://www.scopus.com/inward/record.url?scp=84860015200&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860015200&partnerID=8YFLogxK
U2 - 10.1016/j.addr.2012.01.004
DO - 10.1016/j.addr.2012.01.004
M3 - Review article
C2 - 22306489
AN - SCOPUS:84860015200
VL - 64
SP - 590
EP - 597
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
SN - 0169-409X
IS - 7
ER -