Abstract
The majority of newly diagnosed brain tumors are treated with surgery, radiation, and the chemotherapeutic temozolomide. Development of additional therapeutics to improve treatment outcomes is complicated by the blood-brain barrier (BBB), which acts to protect healthy tissue from chemical insults. The high pressure found within brain tumors adds a challenge to local delivery of therapy by limiting the distribution of bolus injections. Here we discuss various drug delivery strategies, including convection-enhanced delivery, intranasal delivery, and intrathecal delivery, as well as pharmacological strategies for improving therapeutic efficacy, such as blood-brain barrier disruption.
Original language | English (US) |
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Pages (from-to) | 590-597 |
Number of pages | 8 |
Journal | Advanced Drug Delivery Reviews |
Volume | 64 |
Issue number | 7 |
DOIs | |
State | Published - May 15 2012 |
Keywords
- CED
- Chemotherapy
- Convection-enhanced delivery
- Glioblastoma
- Glioma
- Intranasal
- Intrathecal
- Liposome
ASJC Scopus subject areas
- Pharmaceutical Science