Challenges in drug delivery to tumors of the central nervous system: An overview of pharmacological and surgical considerations

Laura P. Serwer; C. David James

doi:10.1016/j.addr.2012.01.004

Challenges in drug delivery to tumors of the central nervous system: An overview of pharmacological and surgical considerations

Laura P. Serwer, C. David James^*

^*Corresponding author for this work

Neurological Surgery

Research output: Contribution to journal › Review article › peer-review

98 Scopus citations

Abstract

The majority of newly diagnosed brain tumors are treated with surgery, radiation, and the chemotherapeutic temozolomide. Development of additional therapeutics to improve treatment outcomes is complicated by the blood-brain barrier (BBB), which acts to protect healthy tissue from chemical insults. The high pressure found within brain tumors adds a challenge to local delivery of therapy by limiting the distribution of bolus injections. Here we discuss various drug delivery strategies, including convection-enhanced delivery, intranasal delivery, and intrathecal delivery, as well as pharmacological strategies for improving therapeutic efficacy, such as blood-brain barrier disruption.

Original language	English (US)
Pages (from-to)	590-597
Number of pages	8
Journal	Advanced Drug Delivery Reviews
Volume	64
Issue number	7
DOIs	https://doi.org/10.1016/j.addr.2012.01.004
State	Published - May 15 2012

Keywords

CED
Chemotherapy
Convection-enhanced delivery
Glioblastoma
Glioma
Intranasal
Intrathecal
Liposome

ASJC Scopus subject areas

Pharmaceutical Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.addr.2012.01.004

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title = "Challenges in drug delivery to tumors of the central nervous system: An overview of pharmacological and surgical considerations",

abstract = "The majority of newly diagnosed brain tumors are treated with surgery, radiation, and the chemotherapeutic temozolomide. Development of additional therapeutics to improve treatment outcomes is complicated by the blood-brain barrier (BBB), which acts to protect healthy tissue from chemical insults. The high pressure found within brain tumors adds a challenge to local delivery of therapy by limiting the distribution of bolus injections. Here we discuss various drug delivery strategies, including convection-enhanced delivery, intranasal delivery, and intrathecal delivery, as well as pharmacological strategies for improving therapeutic efficacy, such as blood-brain barrier disruption.",

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AU - James, C. David

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N2 - The majority of newly diagnosed brain tumors are treated with surgery, radiation, and the chemotherapeutic temozolomide. Development of additional therapeutics to improve treatment outcomes is complicated by the blood-brain barrier (BBB), which acts to protect healthy tissue from chemical insults. The high pressure found within brain tumors adds a challenge to local delivery of therapy by limiting the distribution of bolus injections. Here we discuss various drug delivery strategies, including convection-enhanced delivery, intranasal delivery, and intrathecal delivery, as well as pharmacological strategies for improving therapeutic efficacy, such as blood-brain barrier disruption.

AB - The majority of newly diagnosed brain tumors are treated with surgery, radiation, and the chemotherapeutic temozolomide. Development of additional therapeutics to improve treatment outcomes is complicated by the blood-brain barrier (BBB), which acts to protect healthy tissue from chemical insults. The high pressure found within brain tumors adds a challenge to local delivery of therapy by limiting the distribution of bolus injections. Here we discuss various drug delivery strategies, including convection-enhanced delivery, intranasal delivery, and intrathecal delivery, as well as pharmacological strategies for improving therapeutic efficacy, such as blood-brain barrier disruption.

KW - CED

KW - Chemotherapy

KW - Convection-enhanced delivery

KW - Glioblastoma

KW - Glioma

KW - Intranasal

KW - Intrathecal

KW - Liposome

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Challenges in drug delivery to tumors of the central nervous system: An overview of pharmacological and surgical considerations

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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