Challenges of alloimmunization in patients with haemoglobinopathies

Stella T. Chou, Robert I. Liem, Alexis A. Thompson*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

85 Scopus citations


Red blood cell (RBC) transfusions can be life-sustaining in chronic inherited anaemias, such as thalassaemia, and the indications for blood transfusions in patients with sickle cell disease continue to expand. Complications of transfusions, such as allosensitization, can create significant medical challenges in the management of patients with haemoglobinopathies. This review summarizes key findings from the medical literature related to alloimmunization in haemoglobinopathies and examines potential measures to mitigate these risks. Areas where future studies are needed are also addressed.

Original languageEnglish (US)
Pages (from-to)394-404
Number of pages11
JournalBritish Journal of Haematology
Issue number4
StatePublished - Nov 2012


  • Alloimmunization
  • Haemoglobinopathies
  • Sickle cell disease
  • Thalassaemia
  • Transfusion

ASJC Scopus subject areas

  • Hematology

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