Challenges of alloimmunization in patients with haemoglobinopathies

Stella T. Chou, Robert I Liem, Alexis A Thompson*

*Corresponding author for this work

Research output: Contribution to journalReview article

69 Citations (Scopus)

Abstract

Red blood cell (RBC) transfusions can be life-sustaining in chronic inherited anaemias, such as thalassaemia, and the indications for blood transfusions in patients with sickle cell disease continue to expand. Complications of transfusions, such as allosensitization, can create significant medical challenges in the management of patients with haemoglobinopathies. This review summarizes key findings from the medical literature related to alloimmunization in haemoglobinopathies and examines potential measures to mitigate these risks. Areas where future studies are needed are also addressed.

Original languageEnglish (US)
Pages (from-to)394-404
Number of pages11
JournalBritish Journal of Haematology
Volume159
Issue number4
DOIs
StatePublished - Nov 1 2012

Fingerprint

Hemoglobinopathies
Erythrocyte Transfusion
Thalassemia
Sickle Cell Anemia
Blood Transfusion
Anemia

Keywords

  • Alloimmunization
  • Haemoglobinopathies
  • Sickle cell disease
  • Thalassaemia
  • Transfusion

ASJC Scopus subject areas

  • Hematology

Cite this

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Challenges of alloimmunization in patients with haemoglobinopathies. / Chou, Stella T.; Liem, Robert I; Thompson, Alexis A.

In: British Journal of Haematology, Vol. 159, No. 4, 01.11.2012, p. 394-404.

Research output: Contribution to journalReview article

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AU - Liem, Robert I

AU - Thompson, Alexis A

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AB - Red blood cell (RBC) transfusions can be life-sustaining in chronic inherited anaemias, such as thalassaemia, and the indications for blood transfusions in patients with sickle cell disease continue to expand. Complications of transfusions, such as allosensitization, can create significant medical challenges in the management of patients with haemoglobinopathies. This review summarizes key findings from the medical literature related to alloimmunization in haemoglobinopathies and examines potential measures to mitigate these risks. Areas where future studies are needed are also addressed.

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