Challenges of detecting bioterrorism agents in complex matrices

Erica M. Hartmann, Rolf U. Halden

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations


This chapter offers an overview of the shift from the use of mass-spectrometry for studying purified bioterrorism agents to the development of methods for rapid detection thereof in environmental and clinical samples. We discuss the difficulties of working with such complex matrices and present methods for quickly and effectively reducing complexity through sample preparation. Finally, we examine a success story wherein the common pathogen and potential bioterrorism agent norovirus is detected at clinically relevant levels in human stool.

Original languageEnglish (US)
Title of host publicationDetection of Biological Agents for the Prevention of Bioterrorism
PublisherSpringer Verlag
Number of pages14
ISBN (Print)9789048198146
StatePublished - 2011

Publication series

NameNATO Science for Peace and Security Series A: Chemistry and Biology
ISSN (Print)1874-6489


  • Environmental samples
  • clinical samples
  • norovirus
  • stool

ASJC Scopus subject areas

  • General Chemistry
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Safety, Risk, Reliability and Quality


Dive into the research topics of 'Challenges of detecting bioterrorism agents in complex matrices'. Together they form a unique fingerprint.

Cite this