Challenges of detecting bioterrorism agents in complex matrices

Erica M. Hartmann; Rolf U. Halden

doi:10.1007/978-90-481-9815-3_10

Challenges of detecting bioterrorism agents in complex matrices

Erica M. Hartmann, Rolf U. Halden

Civil and Environmental Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

This chapter offers an overview of the shift from the use of mass-spectrometry for studying purified bioterrorism agents to the development of methods for rapid detection thereof in environmental and clinical samples. We discuss the difficulties of working with such complex matrices and present methods for quickly and effectively reducing complexity through sample preparation. Finally, we examine a success story wherein the common pathogen and potential bioterrorism agent norovirus is detected at clinically relevant levels in human stool.

Original language	English (US)
Title of host publication	Detection of Biological Agents for the Prevention of Bioterrorism
Publisher	Springer Verlag
Pages	149-162
Number of pages	14
ISBN (Print)	9789048198146
DOIs	https://doi.org/10.1007/978-90-481-9815-3_10
State	Published - 2011

Publication series

Name	NATO Science for Peace and Security Series A: Chemistry and Biology
ISSN (Print)	1874-6489

Keywords

Environmental samples
clinical samples
norovirus
stool

ASJC Scopus subject areas

Chemistry(all)
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Safety, Risk, Reliability and Quality

Access to Document

10.1007/978-90-481-9815-3_10

Cite this

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abstract = "This chapter offers an overview of the shift from the use of mass-spectrometry for studying purified bioterrorism agents to the development of methods for rapid detection thereof in environmental and clinical samples. We discuss the difficulties of working with such complex matrices and present methods for quickly and effectively reducing complexity through sample preparation. Finally, we examine a success story wherein the common pathogen and potential bioterrorism agent norovirus is detected at clinically relevant levels in human stool.",

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AU - Halden, Rolf U.

PY - 2011

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AB - This chapter offers an overview of the shift from the use of mass-spectrometry for studying purified bioterrorism agents to the development of methods for rapid detection thereof in environmental and clinical samples. We discuss the difficulties of working with such complex matrices and present methods for quickly and effectively reducing complexity through sample preparation. Finally, we examine a success story wherein the common pathogen and potential bioterrorism agent norovirus is detected at clinically relevant levels in human stool.

KW - Environmental samples

KW - clinical samples

KW - norovirus

KW - stool

UR - http://www.scopus.com/inward/record.url?scp=78650437251&partnerID=8YFLogxK

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U2 - 10.1007/978-90-481-9815-3_10

DO - 10.1007/978-90-481-9815-3_10

M3 - Conference contribution

AN - SCOPUS:78650437251

SN - 9789048198146

T3 - NATO Science for Peace and Security Series A: Chemistry and Biology

SP - 149

EP - 162

BT - Detection of Biological Agents for the Prevention of Bioterrorism

PB - Springer Verlag

ER -

Challenges of detecting bioterrorism agents in complex matrices

Abstract

Publication series

Keywords

ASJC Scopus subject areas

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