Change, exchange, and rearrange: Protein engineering for the biotechnological production of fuels, pharmaceuticals, and other chemicals

Michael A. Fisher, Danielle Tullman-Ercek*

*Corresponding author for this work

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

Enzymes are indispensable in the effort to produce chemicals from fuels to pharmaceuticals in an ecologically friendly manner. They have the potential to catalyze reactions with high specificity and efficiency without the use of hazardous chemicals. Nature provides an extensive collection of enzymes, but often these must be altered to perform desired functions under required conditions. Advances in protein engineering permit the design and/or directed evolution of enzymes specifically tailored for such industrial applications. Recent years have seen the development of improved enzymes to assist in both the conversion of biomass into fuels and chemicals, and the creation of key intermediates in pharmaceutical production.

Original languageEnglish (US)
Pages (from-to)1010-1016
Number of pages7
JournalCurrent Opinion in Biotechnology
Volume24
Issue number6
DOIs
StatePublished - Dec 1 2013

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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