Changes in arterial cerebral blood volume during lower body negative pressure measured with MRI

Joseph R. Whittaker*, Molly G. Bright, Ian D. Driver, Adele Babic, Sharmila Khot, Kevin Murphy

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Cerebral Autoregulation (CA), defined as the ability of the cerebral vasculature to maintain stable levels of blood flow despite changes in systemic blood pressure, is a critical factor in neurophysiological health. Magnetic resonance imaging (MRI) is a powerful technique for investigating cerebrovascular function, offering high spatial resolution and wide fields of view (FOV), yet it is relatively underutilized as a tool for assessment of CA. The aim of this study was to demonstrate the potential of using MRI to measure changes in cerebrovascular resistance in response to lower body negative pressure (LBNP). A Pulsed Arterial Spin Labeling (PASL) approach with short inversion times (TI) was used to estimate cerebral arterial blood volume (CBV a ) in eight healthy subjects at baseline and −40 mmHg LBNP. We estimated group mean CBV a values of 3.13 ± 1.00 and 2.70 ± 0.38 for baseline and lbnp respectively, which were the result of a differential change in CBV a during −40 mmHg LBNP that was dependent on baseline CBV a . These data suggest that the PASL CBV a estimates are sensitive to the complex cerebrovascular response that occurs during the moderate orthostatic challenge delivered by LBNP, which we speculatively propose may involve differential changes in vascular tone within different segments of the arterial vasculature. These novel data provide invaluable insight into the mechanisms that regulate perfusion of the brain, and establishes the use of MRI as a tool for studying CA in more detail.

Original languageEnglish (US)
Pages (from-to)166-175
Number of pages10
JournalNeuroimage
Volume187
DOIs
StatePublished - Feb 15 2019

Fingerprint

Lower Body Negative Pressure
Magnetic Resonance Imaging
Homeostasis
Blood Vessels
Healthy Volunteers
Perfusion
Blood Pressure
Cerebral Blood Volume
Health
Brain

Keywords

  • Arterial spin labeling
  • Cerebral autoregulation
  • Cerebral blood volume
  • Lower body negative pressure
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

Cite this

Whittaker, Joseph R. ; Bright, Molly G. ; Driver, Ian D. ; Babic, Adele ; Khot, Sharmila ; Murphy, Kevin. / Changes in arterial cerebral blood volume during lower body negative pressure measured with MRI. In: Neuroimage. 2019 ; Vol. 187. pp. 166-175.
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Changes in arterial cerebral blood volume during lower body negative pressure measured with MRI. / Whittaker, Joseph R.; Bright, Molly G.; Driver, Ian D.; Babic, Adele; Khot, Sharmila; Murphy, Kevin.

In: Neuroimage, Vol. 187, 15.02.2019, p. 166-175.

Research output: Contribution to journalArticle

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AU - Driver, Ian D.

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AU - Murphy, Kevin

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