Changes in blood coagulation, platelet function, and plasminogen-plasmin system in diabetes

Hau C. Kwaan*

*Corresponding author for this work

Research output: Contribution to journalArticle

79 Scopus citations

Abstract

The increased risk of thromboembolism in people with diabetes mellitus is in part due to changes in the hemostatic mechanism including abnormal platelet function leading to platelet activation, increase in several coagulation factors, decrease in natural anticoagulants, and impaired fibrinolytic activity. Both microangiopathy and atherosclerosis in people with diabetes will enhance the thrombotic potential of these abnormal hemostatic changes. The recent recognition of a role of the components of the plasminogen-plasmin system in many biologic functions at the cellular level has led to studies showing that the angiopathic complications of diabetes may also be caused by impaired plasminogen activator function.

Original languageEnglish (US)
Pages (from-to)32-35
Number of pages4
JournalDiabetes
Volume41
Issue numberSUPPL. 2
StatePublished - Jan 1 1992

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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