Changes in body shape implicate cuticle stretch in C. elegans growth control

Joy Nyaanga, Christina Goss, Gaotian Zhang, Hannah N. Ahmed, Elliot J. Andersen, Isabella R. Miller, Justine K. Rozenich, Iris L. Swarthout, Jordan A. Vaughn, Niall M. Mangan, Sasha Shirman, Erik C. Andersen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Growth control establishes organism size, requiring mechanisms to sense and adjust growth during development. Studies of single cells revealed that size homeostasis uses distinct control methods. In multicellular organisms, mechanisms that regulate single cell growth must integrate control across organs and tissues during development to generate adult size and shape. We leveraged the roundworm Caenorhabditis elegans as a scalable and tractable model to collect precise growth measurements of thousands of individuals, measure feeding behavior, and quantify changes in animal size and shape during a densely sampled developmental time course. As animals transitioned from one developmental stage to the next, we observed changes in body aspect ratio while body volume remained constant. Then, we modeled a physical mechanism by which constraints on cuticle stretch could cause changes in C. elegans body shape. The model-predicted shape changes are consistent with those observed in the data. Theoretically, cuticle stretch could be sensed by the animal to initiate larval-stage transitions, providing a means for physical constraints to influence developmental timing and growth rate in C. elegans.

Original languageEnglish (US)
Article number203780
JournalCells and Development
StatePublished - Jun 2022


  • C. elegans
  • Developmental growth
  • Growth control

ASJC Scopus subject areas

  • Medicine(all)
  • Developmental Biology


Dive into the research topics of 'Changes in body shape implicate cuticle stretch in C. elegans growth control'. Together they form a unique fingerprint.

Cite this