Changes in cerebral blood flow and recovery from

Allan M. Burke*, Donald Younkin, John Gordon, Herbert Goldberg, Thomas Graham, Michael Kushner, Walter Obrjst, Jurg Jaggi, Mitchell Rosen, Martin Reivich

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


We prospectively studied 14 patients with acute cerebral infarctions using serial I33Xenon inhalation cerebral determination (133Xe-rCBF), scored neurological examinations, and neuropsycholog-icai testing. All patients underwent the same battery of tests at 3 days, 1 week, 2 weeks, and 4 weeks after cerebral infarction to determine the prognostic value of early rCBF studies and the chronological relationship of changes in rCBF to clinical status. Baseline rCBF within 3 days of symptoms of acute stroke did not correlate with clinical neurological outcome (r = - 0.17, p< 0.30; r = - 0.18, p< 0.28, for the two indices of rCBF used). Among the 11 patients demonstrating neurological recovery, 7 improved at 1 week, significantly before increases in rCBF (p < 0.05). We conclude that early baseline rCBF does not predict clinical outcome in patients with acute cerebral infarctions and that return of neurological function precedes rather than follows increases in rCBF.

Original languageEnglish (US)
Pages (from-to)173-178
Number of pages6
Issue number2
StatePublished - 1986

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing


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