TY - JOUR
T1 - Changes in cortical network connectivity with long-Term brain-machine interface exposure after chronic amputation
AU - Balasubramanian, Karthikeyan
AU - Vaidya, Mukta
AU - Southerland, Joshua
AU - Badreldin, Islam
AU - Eleryan, Ahmed
AU - Takahashi, Kazutaka
AU - Qian, Kai
AU - Slutzky, Marc W.
AU - Fagg, Andrew H.
AU - Oweiss, Karim
AU - Hatsopoulos, Nicholas G.
N1 - Funding Information:
This work was supported by the Defense Advanced Research Projects Agency (DARPA) grant N66 001-12-1-4023 (K.B., M.V., J.S., I.B., A.E., M.S., A.H.F., K.O., and N.G.H), National Institute of Neurological Disorders and Stroke (NINDS) grant R01 NS 045853 (K.B., and N.G.H.), National Institute of Dental and Craniofacial Research (NIDCR) grant R01 DE023816 (K.T., and N.G.H.), National Institutes of Health (NIH) grants NS 062031 (K.O., I.B., and A.E.) and NS 93909 (K.O.), and National Science Foundation (NSF) grant 1504954 (K.O.). This work used the Beagle supercomputer resources provided by the Computation Institute and the Biological Sciences Division of the University of Chicago and Argonne National Laboratory, and the Midway cluster at the Research Computing Center of the University of Chicago.
Publisher Copyright:
© 2017 The Author(s).
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Studies on neural plasticity associated with brain-machine interface (BMI) exposure have primarily documented changes in single neuron activity, and largely in intact subjects. Here, we demonstrate significant changes in ensemble-level functional connectivity among primary motor cortical (MI) neurons of chronically amputated monkeys exposed to control a multiple-degree-of-freedom robot arm. A multi-electrode array was implanted in M1 contralateral or ipsilateral to the amputation in three animals. Two clusters of stably recorded neurons were arbitrarily assigned to control reach and grasp movements, respectively. With exposure, network density increased in a nearly monotonic fashion in the contralateral monkeys, whereas the ipsilateral monkey pruned the existing network before re-forming a denser connectivity. Excitatory connections among neurons within a cluster were denser, whereas inhibitory connections were denser among neurons across the two clusters. These results indicate that cortical network connectivity can be modified with BMI learning, even among neurons that have been chronically de-efferented and de-Afferented due to amputation.
AB - Studies on neural plasticity associated with brain-machine interface (BMI) exposure have primarily documented changes in single neuron activity, and largely in intact subjects. Here, we demonstrate significant changes in ensemble-level functional connectivity among primary motor cortical (MI) neurons of chronically amputated monkeys exposed to control a multiple-degree-of-freedom robot arm. A multi-electrode array was implanted in M1 contralateral or ipsilateral to the amputation in three animals. Two clusters of stably recorded neurons were arbitrarily assigned to control reach and grasp movements, respectively. With exposure, network density increased in a nearly monotonic fashion in the contralateral monkeys, whereas the ipsilateral monkey pruned the existing network before re-forming a denser connectivity. Excitatory connections among neurons within a cluster were denser, whereas inhibitory connections were denser among neurons across the two clusters. These results indicate that cortical network connectivity can be modified with BMI learning, even among neurons that have been chronically de-efferented and de-Afferented due to amputation.
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U2 - 10.1038/s41467-017-01909-2
DO - 10.1038/s41467-017-01909-2
M3 - Article
C2 - 29180616
AN - SCOPUS:85035798553
VL - 8
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
IS - 1
M1 - 1796
ER -