Changes in glucose uptake by malignant gliomas: preliminary study of prognostic significance

Jack M. Rozental*, Ross L. Levine, Robert J. Nickles

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Sequential positron emission tomographic scans with [18F]-2-fluorodeoxyglucose (PET-FDG) were performed on 14 patients with malignant gliomas. All patients had prior brain irradiation. Five patients received adjuvant eight-drugs-in-one-day chemotherapy (experimental subjects) and 9 did not (control subjects). Ratios between the maximal tumor regional cerebral metabolic rate for glucose (rCMRGlu) and the contralateral white matter rCMRGlu, the glucose uptake ratio, were determined. Percent changes in the ratio 1 day after chemotherapy in experimental subjects, and 30 days after the baseline scan in controls, were of prognostic significance. In both groups, patients with the largest percent changes in rCMRGlu had the shortest survival. In contrast, the baseline glucose uptake ratio did not predict length of survival.

Original languageEnglish (US)
Pages (from-to)75-83
Number of pages9
JournalJournal of Neuro-Oncology
Volume10
Issue number1
DOIs
StatePublished - Feb 1991

Keywords

  • PET scan
  • malignant glioma
  • patient prognosis
  • tumor bioenergetics

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

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