Abstract
Glycolipid glycosyltransferase activities involved in the biosynthesis in vitro of neutral and acidic glycosphingolipids were measured in C-1300 tumors and cloned cells derived therefrom. An adrenergic clone (NIE-115) was grown in tissue culture in the presence of dibutyryl cyclic AMP and the levels of glycosyltransferases were measured before and after differentiation. Increased activities of galactosyltransferases and sialyl-transferases with a concomitant increase in glutamate decarboxylase activity (the enzyme that catalyzes the synthesis of an inhibitory neurotransmitter, γ-aminobutyric acid) were observed.
Original language | English (US) |
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Pages (from-to) | 751-758 |
Number of pages | 8 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 61 |
Issue number | 2 |
DOIs | |
State | Published - Nov 27 1974 |
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology