Changes in mechanical work during neural adaptation to asymmetric locomotion

Brian P. Selgrade, Montakan Thajchayapong, Gloria E. Lee, Megan E. Toney, Young Hui Chang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Minimizing whole-body metabolic cost has been suggested to drive the neural processes of locomotor adaptation. Mechanical work performed by the legs should dictate the major changes in wholebody metabolic cost of walking while providing greater insight into temporal and spatial mechanisms of adaptation. We hypothesized that changes in mechanical work by the legs during an asymmetric split-belt walking adaptation task could explain previously observed changes in whole-body metabolic cost. We predicted that subjects would immediately increase mechanical work performed by the legs when first exposed to split-belt walking, followed by a gradual decrease throughout adaptation. Fourteen subjects walked on a dualbelt instrumented treadmill. Baseline trials were followed by a 10-min split-belt adaptation condition with one belt running three times faster than the other. A post-adaptation trial with both belts moving at 0.5 m s-1 demonstrated neural adaptation. As predicted, summed mechanical work from both legs initially increased abruptly and gradually decreased over the adaptation period. The initial increase in work was primarily due to increased positive work by the leg on the fast belt during the pendular phase of the gait cycle. Neural adaptation in asymmetric split-belt walking reflected the reduction of pendular phase work in favor of more economical step-to-step transition work. This may represent a generalizable framework for how humans initially and chronically learn new walking patterns.

Original languageEnglish (US)
Pages (from-to)2993-3000
Number of pages8
JournalJournal of Experimental Biology
Volume220
Issue number16
DOIs
StatePublished - Aug 15 2017

Funding

This work was supported by National Institute of Neurological Disorders and Stroke (NINDS) 5R01NS069655 and National Institute of Child Health and Human Development (NICHD) 5T32HD055180. Deposited in PMC for release after 12 months.

Keywords

  • Biomechanics
  • Locomotor adaptation
  • Mechanical work
  • Motor control
  • Split-belt treadmill

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Physiology
  • Aquatic Science
  • Animal Science and Zoology
  • Molecular Biology
  • Insect Science

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