Changes in pro-oxidant-antioxidant balance after bare metal and drug eluting stent implantation in patients with stable coronary disease

Homa Falsoleiman, Mashalla Dehghani, Mohsen Moohebati, Afsoon Fazlinezhad, Mahdi Hassanzadeh Daloee, Daryoush Hamidi Alamdari, Habib Ollah Esmaily, Seyyed Mohammad Reza Parizadeh, Shima Tavallaie, Amir Ali Rahsepar, Roghayeh Paydar, Seyyed Mohammad Reza Kazemi-Bajestani, Hossein Pourghadam-Yari, Parisa Abbasi Parizad, Majid Ghayour-Mobarhan*, Gordon A. Ferns

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Objectives: In this study we aimed to assess the changes in pro-oxidant-antioxidant balance (PAB) after the placement of either a drug-eluting-stent (DES) or bare-metal-stent (BMS) in patients with stable coronary artery disease. Design and methods: Percutaneous coronary interventions (PCI) with either BMS or DES were undertaken for 152 patients (82 in the BMS and 70 in the DES groups respectively). PAB values were measured 24. h before and after PCI. Results: Baseline PAB values were 80.68 (64.98-99.37) and 98.86 (64.70-140.62) for BMS and DES group, respectively, which were not significantly different between the 2 groups (P> 0.05). Following PCI, median PAB values decreased to 72.10 (61.40-96.13) and 81.40 (54.15-121.90) in BMS and DES groups, respectively. The reduction was significant in both BMS and DES groups (P< 0.05). The changes in PAB values were -2.81 (-12.76 to 2.31) for BMS and -2.82 (-29.88 to 8.93) for DES group, which were not significantly different between the 2 groups (P> 0.05). Conclusion: We found that the reported difference in clinical outcomes following DES or BMS implantation cannot be attributed to differences in early changes in oxidative stress induction as assessed by changes in PAB values.

Original languageEnglish (US)
Pages (from-to)160-164
Number of pages5
JournalClinical Biochemistry
Volume44
Issue number2-3
DOIs
StatePublished - Feb 2011

Funding

We are particularly grateful to the patients and their family members who volunteered to participate in this study. This work was supported by Mashhad University of Medical Science (MUMS), Iran .

Keywords

  • Angioplasty
  • Bare metal and Drug eluting Stents
  • Oxidative Stress

ASJC Scopus subject areas

  • Clinical Biochemistry

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