TY - JOUR
T1 - Changes in pro-oxidant-antioxidant balance after bare metal and drug eluting stent implantation in patients with stable coronary disease
AU - Falsoleiman, Homa
AU - Dehghani, Mashalla
AU - Moohebati, Mohsen
AU - Fazlinezhad, Afsoon
AU - Daloee, Mahdi Hassanzadeh
AU - Alamdari, Daryoush Hamidi
AU - Esmaily, Habib Ollah
AU - Parizadeh, Seyyed Mohammad Reza
AU - Tavallaie, Shima
AU - Rahsepar, Amir Ali
AU - Paydar, Roghayeh
AU - Kazemi-Bajestani, Seyyed Mohammad Reza
AU - Pourghadam-Yari, Hossein
AU - Parizad, Parisa Abbasi
AU - Ghayour-Mobarhan, Majid
AU - Ferns, Gordon A.
PY - 2011/2
Y1 - 2011/2
N2 - Objectives: In this study we aimed to assess the changes in pro-oxidant-antioxidant balance (PAB) after the placement of either a drug-eluting-stent (DES) or bare-metal-stent (BMS) in patients with stable coronary artery disease. Design and methods: Percutaneous coronary interventions (PCI) with either BMS or DES were undertaken for 152 patients (82 in the BMS and 70 in the DES groups respectively). PAB values were measured 24. h before and after PCI. Results: Baseline PAB values were 80.68 (64.98-99.37) and 98.86 (64.70-140.62) for BMS and DES group, respectively, which were not significantly different between the 2 groups (P> 0.05). Following PCI, median PAB values decreased to 72.10 (61.40-96.13) and 81.40 (54.15-121.90) in BMS and DES groups, respectively. The reduction was significant in both BMS and DES groups (P< 0.05). The changes in PAB values were -2.81 (-12.76 to 2.31) for BMS and -2.82 (-29.88 to 8.93) for DES group, which were not significantly different between the 2 groups (P> 0.05). Conclusion: We found that the reported difference in clinical outcomes following DES or BMS implantation cannot be attributed to differences in early changes in oxidative stress induction as assessed by changes in PAB values.
AB - Objectives: In this study we aimed to assess the changes in pro-oxidant-antioxidant balance (PAB) after the placement of either a drug-eluting-stent (DES) or bare-metal-stent (BMS) in patients with stable coronary artery disease. Design and methods: Percutaneous coronary interventions (PCI) with either BMS or DES were undertaken for 152 patients (82 in the BMS and 70 in the DES groups respectively). PAB values were measured 24. h before and after PCI. Results: Baseline PAB values were 80.68 (64.98-99.37) and 98.86 (64.70-140.62) for BMS and DES group, respectively, which were not significantly different between the 2 groups (P> 0.05). Following PCI, median PAB values decreased to 72.10 (61.40-96.13) and 81.40 (54.15-121.90) in BMS and DES groups, respectively. The reduction was significant in both BMS and DES groups (P< 0.05). The changes in PAB values were -2.81 (-12.76 to 2.31) for BMS and -2.82 (-29.88 to 8.93) for DES group, which were not significantly different between the 2 groups (P> 0.05). Conclusion: We found that the reported difference in clinical outcomes following DES or BMS implantation cannot be attributed to differences in early changes in oxidative stress induction as assessed by changes in PAB values.
KW - Angioplasty
KW - Bare metal and Drug eluting Stents
KW - Oxidative Stress
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U2 - 10.1016/j.clinbiochem.2010.10.009
DO - 10.1016/j.clinbiochem.2010.10.009
M3 - Article
C2 - 21070760
AN - SCOPUS:79151479233
SN - 0009-9120
VL - 44
SP - 160
EP - 164
JO - Clinical Biochemistry
JF - Clinical Biochemistry
IS - 2-3
ER -