Changes in QT dispersion during adenosine infusion

A. Kumar, C. Narasimhan, A. Sankari, A. Ranginani, C. Lennon, C. Bekerman, W. Clark, P. Denes, D. Lieb*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Background: QT dispersion (QTd) measurement during treadmill stress testing has been to shown to improve the accuracy of exercise electrocardiogram (ECG) in the detection of significant coronary artery disease (CAD). Hypothesis: The aim of this study was to determine whether adenosine-induced changes in QTd could predict significant CAD and to assess its efficacy as a diagnostic index in patients undergoing adenosine stress test. Methods: QT interval measurements were made in 57 consecutive patients undergoing adenosine sestamibi stress test. Patients with an abnormal stress test underwent coronary angiography. Patients with significant disease by coronary angiography (< 70% stenosis) were classified as having CAD (Group 1), and those with normal stress images and/or normal coronaries by angiography were classified as having no CAD (Group 2). Results: QT dispersion increased from 28.2 ± 4.5 to 43.8 ± 4.5 ms with a ΔQTd of 15.53 ± 3.68 in Group 1 (p=0.001) and from 28.4 ± 2.6 to 34.8 ± 2.8 ms with a ΔQTd of 6.58 ± 2.21 ms in Group 2 (p = 0.006). Patients in Group 1 had a significantly higher increase in QTd (ΔQTd) than the patients in Group 2 (p < 0.03). Addition of ΔQTd (> 10 ms) to the ST depression during adenosine infusion would increase the sensitivity of the ECG from 23 to 65% and decrease the specificity from 91 to 70% for diagnosis of significant CAD. Conclusions: ΔQTd is significantly more prolonged in patients with CAD during adenosine infusion. It increases the sensitivity of the stress ECG in diagnosis of CAD during adenosine infusion when used as an adjuvant index.

Original languageEnglish (US)
Pages (from-to)760-762
Number of pages3
JournalClinical Cardiology
Issue number10
StatePublished - 2000


  • Adenosine
  • QT dispersion
  • Repolarization
  • Stress testing

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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