Changes in Scleral Architecture in Chronic Vogt–Koyanagi–Harada Disease

Yosuke Harada, Pooja Bhat, Marion R. Munk, Debra A. Goldstein*

*Corresponding author for this work

Research output: Contribution to journalComment/debatepeer-review

8 Scopus citations


Purpose: To describe scleral changes in chronic VKH. Methods: Medical records of patients with chronic VKH were retrospectively reviewed. Change of scleral architecture was defined as progressive posterior bowing on OCT, axial length elongation, and/or increased myopia more than –1.0 D, not explicable by other etiologies. Results: In total, 28 eyes (16 patients) with mean age of disease onset 32.5 ± 14.0 years were included in the study. Disease duration was 15.1 ± 10.2 years. Eight eyes (28.6%) showed progressive scleral architectural changes. Five eyes (18%) developed scleral changes on OCT, not seen on prior imaging (2–12 years earlier). One eye had posterior bowing on OCT with increased axial length, both eyes of a bilateral pseudophake developed increased myopia with increased axial length. Well-circumscribed chorioretinal atrophy within the arcade was associated with progressive scleral change. Conclusions: Progressive scleral change may develop as a late complication of VKH. The association with well-circumscribed chorioretinal atrophy suggests that chronic choroidal inflammation may be responsible.

Original languageEnglish (US)
Pages (from-to)85-92
Number of pages8
JournalOcular Immunology and Inflammation
Issue number1
StatePublished - Jan 2 2017


  • OCT
  • VKH
  • choroid
  • sclera
  • uveitis

ASJC Scopus subject areas

  • Ophthalmology
  • Immunology and Allergy


Dive into the research topics of 'Changes in Scleral Architecture in Chronic Vogt–Koyanagi–Harada Disease'. Together they form a unique fingerprint.

Cite this