Changes in small dense low-density lipoprotein levels following acute coronary syndrome

Mahdi Reza Emadzadeh, Maryam Sadat Alavi, Mohammad Soukhtanloo, Toktam Mohammadpour, Amir Ali Rahsepar, Shima Tavallaie, Roshanak Khojasteh, Roghayeh Paydar, Maral Amini, Seyyed Mohammad Reza Parizadeh, Saeed Akhlaghi, Majid Ghayour-Mobarhan*, Gordon A. Ferns

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Low-density lipoprotein (LDL), especially small dense LDL (sdLDL), plays a role in atherogenesis. We compared baseline sdLDL levels between healthy controls and patients with acute coronary syndrome (ACS). Blood samples were taken from patients diagnosed with myocardial infarction ([MI] n = 104) and unstable angina ([UA] n = 100). Both sdLDL and high-sensitivity C-reactive protein (hsCRP) levels were determined on admission and in the next 24 hours after the onset of symptoms. Baseline concentration of sdLDL was significantly higher in patients presenting with ACS than controls (P <.05). In the 24 hours following ACS, the sdLDL levels decreased insignificantly in both groups of patients with ACS (P >.05). The changes in sdLDL values were not significantly different between MI and UA participants (P >.05). Patients with ACS have higher concentration of sdLDL compared with the controls.

Original languageEnglish (US)
Pages (from-to)216-222
Number of pages7
Issue number3
StatePublished - Apr 2013


  • acute coronary syndrome
  • high-sensitive C-reactive protein
  • small dense low-density lipoprotein

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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