Changes in the effects of stimulation of locus coeruleus and nucleus raphe magnus following dorsal rhizotomy

Charles J. Hodge*, A. Vania Apkarian, Michael P. Owen, Brian S. Hanson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

The effects of stimulating locus coeruleus (LC) and nucleus raphe magnus (NRM) on lumbar dorsal horn cells that had been denervated by dorsal rhizotomy were studied. Both LC and NRM stimulation inhibited the responses of dorsal horn cells from the side of the cord with intact dorsal roots. However, when cells from the side of the spinal cord that had had prior rhizotomies were studies, half of the units were shown to be activated by either LC or NRM stimulation.

Original languageEnglish (US)
Pages (from-to)325-329
Number of pages5
JournalBrain research
Volume288
Issue number1-2
DOIs
StatePublished - Dec 12 1983

Funding

This work was supported in part by a gift from the Perkins Foundation. We thank Norma Horton for expert histologic assistance.

Keywords

  • deafferentation
  • dorsal horn
  • locus coeruleus
  • nucleus raphe magnus

ASJC Scopus subject areas

  • Clinical Neurology
  • Molecular Biology
  • General Neuroscience
  • Developmental Biology

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