Changes in the effects of stimulation of locus coeruleus and nucleus raphe magnus following dorsal rhizotomy

Charles J. Hodge; A. Vania Apkarian; Michael P. Owen; Brian S. Hanson

doi:10.1016/0006-8993(83)90111-7

Changes in the effects of stimulation of locus coeruleus and nucleus raphe magnus following dorsal rhizotomy

Charles J. Hodge^*, A. Vania Apkarian, Michael P. Owen, Brian S. Hanson

^*Corresponding author for this work

Neuroscience

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

The effects of stimulating locus coeruleus (LC) and nucleus raphe magnus (NRM) on lumbar dorsal horn cells that had been denervated by dorsal rhizotomy were studied. Both LC and NRM stimulation inhibited the responses of dorsal horn cells from the side of the cord with intact dorsal roots. However, when cells from the side of the spinal cord that had had prior rhizotomies were studies, half of the units were shown to be activated by either LC or NRM stimulation.

Original language	English (US)
Pages (from-to)	325-329
Number of pages	5
Journal	Brain research
Volume	288
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(83)90111-7
State	Published - Dec 12 1983

Funding

This work was supported in part by a gift from the Perkins Foundation. We thank Norma Horton for expert histologic assistance.

Keywords

deafferentation
dorsal horn
locus coeruleus
nucleus raphe magnus

ASJC Scopus subject areas

Clinical Neurology
Molecular Biology
General Neuroscience
Developmental Biology

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10.1016/0006-8993(83)90111-7

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title = "Changes in the effects of stimulation of locus coeruleus and nucleus raphe magnus following dorsal rhizotomy",

abstract = "The effects of stimulating locus coeruleus (LC) and nucleus raphe magnus (NRM) on lumbar dorsal horn cells that had been denervated by dorsal rhizotomy were studied. Both LC and NRM stimulation inhibited the responses of dorsal horn cells from the side of the cord with intact dorsal roots. However, when cells from the side of the spinal cord that had had prior rhizotomies were studies, half of the units were shown to be activated by either LC or NRM stimulation.",

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AU - Hodge, Charles J.

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AU - Hanson, Brian S.

PY - 1983/12/12

Y1 - 1983/12/12

N2 - The effects of stimulating locus coeruleus (LC) and nucleus raphe magnus (NRM) on lumbar dorsal horn cells that had been denervated by dorsal rhizotomy were studied. Both LC and NRM stimulation inhibited the responses of dorsal horn cells from the side of the cord with intact dorsal roots. However, when cells from the side of the spinal cord that had had prior rhizotomies were studies, half of the units were shown to be activated by either LC or NRM stimulation.

AB - The effects of stimulating locus coeruleus (LC) and nucleus raphe magnus (NRM) on lumbar dorsal horn cells that had been denervated by dorsal rhizotomy were studied. Both LC and NRM stimulation inhibited the responses of dorsal horn cells from the side of the cord with intact dorsal roots. However, when cells from the side of the spinal cord that had had prior rhizotomies were studies, half of the units were shown to be activated by either LC or NRM stimulation.

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Changes in the effects of stimulation of locus coeruleus and nucleus raphe magnus following dorsal rhizotomy

Abstract

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Keywords

ASJC Scopus subject areas

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