Abstract
New data published in the literature provided evidence for appearance of an unknown variant of amyloidosis recorded in patients with a 5-15-year history of hemodialysis. Such amyloidosis may result from high blood levels of beta-2-microglobulin unremovable at standard hemodialysis. Even highly permeable membranes which permit beta-2-microglobulin penetration fail to produce negative balance of this metabolite as the procedure stimulates leukocyte activity and, consequently, beta-2-microglobulin production. In spite of the fact that contact of the blood with synthetic materials during hemodialysis is not longer than 3-5 hours, blood elements and endothelial cell metabolism, homeostasis undergo serious alterations. These effects of biocompatibility provoke the condition of enhanced activation similar to chronic inflammation. Thus, we deal with a new phenomenon in the field of hemodialysis. The efforts of investigators should be aimed at studying long-term adaptation of the body which rings atypical picture of chronic diseases.
| Translated title of the contribution | Changes in the picture of chronic diseases on long-term hemodialysis treatment |
|---|---|
| Original language | Russian |
| Pages (from-to) | 25-27 |
| Number of pages | 3 |
| Journal | Urologiia i nefrologiia |
| Issue number | 5 |
| State | Published - Sep 1995 |
ASJC Scopus subject areas
- Nephrology
- Urology