Changes of nitric oxide synthase/cGMP system in hypertensive rats

Y. Z. Wang*, W. A. Qiang, J. Sun, J. S. Liu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Objective: In order to observe the changes of nitric oxide synthase (NOS) activity and cyclic GMP (cGMP) content in cerebellum, liver, kidney, heart and aorta for Wistar-Kyoto rats (WKY), spontaneously hypertensive rats (SHR), normotensive rats, and renovascular hypertensive rats. Methods: Renovascular hypertensive rats were obtained by cliping the kidney artery and NOS activity was assayed by monitoring the conversion of 3H-arginine to 3H- citrulline. Results: Compared with WKY, NOS activity was significantly lower in all organs measured for SHR, NOS activity in the aorta and heart was 52% and 49% lower in SHR (P<0.01), and cGMP content significantly lower in liver, kidney and aorta for SHR. Compared with normotensive rats, NOS activity and cGMP content in the nonclipped kidney was significantly higher in renovascular hypertensive rats (P<0.05). With the exception of the non- clipped kidney, there was no difference in NOS activity and cGMP content in any other organ between renovascular hypertensive and normotensive rats. Conclusions: These findings suggest that a generalized decrease of NOS activity is likely to predispose SHR to an elevation of blood pressure and that, in renovascular hypertensive rats, NOS activity may play a role in the adaptation of local perfusion to the non-clipped kidney under hypertension.

Original languageEnglish (US)
Pages (from-to)120-123
Number of pages4
JournalChinese Pharmacological Bulletin
Volume13
Issue number2
StatePublished - 1997

Keywords

  • Blood pressure
  • Hypertension
  • Inbred SHR
  • Nitric oxide
  • Rats
  • Renovascular
  • cGMP

ASJC Scopus subject areas

  • Pharmacology

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