Chaperone networks: Tipping the balance in protein folding diseases

Cindy Voisine, Jesper Søndergaard Pedersen, Richard I. Morimoto*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

120 Scopus citations


Adult-onset neurodegeneration and other protein conformational diseases are associated with the appearance, persistence, and accumulation of misfolded and aggregation-prone proteins. To protect the proteome from long-term damage, the cell expresses a highly integrated protein homeostasis (proteostasis) machinery to ensure that proteins are properly expressed, folded, and cleared, and to recognize damaged proteins. Molecular chaperones have a central role in proteostasis as they have been shown to be essential to prevent the accumulation of alternate folded proteotoxic states as occurs in protein conformation diseases exemplified by neurodegeneration. Studies using invertebrate models expressing proteins associated with Huntington's disease, Alzheimer's disease, ALS, and Parkinson's disease have provided insights into the genetic networks and stress signaling pathways that regulate the proteostasis machinery to prevent cellular dysfunction, tissue pathology, and organismal failure. These events appear to be further amplified by aging and provide evidence that age-related failures in proteostasis may be a common element in many diseases.

Original languageEnglish (US)
Pages (from-to)12-20
Number of pages9
JournalNeurobiology of Disease
Issue number1
StatePublished - Oct 2010


  • Aggregation
  • Aging
  • Caenorhabditis elegans
  • Molecular chaperones
  • Proteostasis

ASJC Scopus subject areas

  • Neurology

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