Chapter 7 Ciliary Function and Wnt Signal Modulation

Jantje M. Gerdes*, Elias Nicholas Katsanis

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

54 Scopus citations

Abstract

With the increase in complexity of morphogenetic signaling cascades over the course of evolution and the emergence of broadly ciliated organisms, the cilium seems to have acquired a role as regulator of paracrine signal transduction. Recently, several lines of evidence have provided a link between basal body and ciliary proteins and Wnt signaling. In this chapter, we will evaluate the evidence linking the basal body and cilium with the regulation of β-catenin-dependent (canonical) and β-catenin-independent (noncanonical) signaling processes as well as which role(s) Wnt signaling might play in ciliogenesis. In addition, we will discuss aberrant Wnt signaling could contribute to phenotypes common to most ciliopathies and why these phenotypes might be driven by loss of noncanonical rather than gain of noncanonical Wnt signaling.

Original languageEnglish (US)
Title of host publicationCiliary Function in Mammalian Development
EditorsBradley Yoder
Pages175-195
Number of pages21
DOIs
StatePublished - 2008

Publication series

NameCurrent Topics in Developmental Biology
Volume85
ISSN (Print)0070-2153

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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